AG 7352 Hydrochloride
- CAS No.
- 175519-16-1
- Chemical Name:
- AG 7352 Hydrochloride
- Synonyms
- SNS-595 Hydrochloride;AG 7352 Hydrochloride;Voreloxin (SNS-595) HCl;Vosaroxin Hydrochloride;Voreloxin (Hydrochloride);Vosaroxin hydrochloride salt;Voreloxin 13C-D3 Hydrochloride;Voreloxin(SNS-595)hydrochloride;Vosaroxin hydrochloride >=98% (HPLC);Voreloxin Impurity 1 (Hydrochloride)
- CBNumber:
- CB52645152
- Molecular Formula:
- C18H20ClN5O4S
- Molecular Weight:
- 437.9
- MDL Number:
- MFCD00946608
- MOL File:
- 175519-16-1.mol
- MSDS File:
- SDS
AG 7352 Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0927 | VoreloxinHydrochloride 99.96% | 175519-16-1 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0927 | VoreloxinHydrochloride 99.96% | 175519-16-1 | 10mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | A3925 | VoreloxinHydrochloride | 175519-16-1 | 5mg | $221 | 2021-12-16 | Buy |
| ApexBio Technology | A3925 | VoreloxinHydrochloride | 175519-16-1 | 10mg | $378 | 2021-12-16 | Buy |
| ChemScene | CS-0927 | VoreloxinHydrochloride 99.96% | 175519-16-1 | 50mg | $750 | 2021-12-16 | Buy |
AG 7352 Hydrochloride Chemical Properties,Uses,Production
Uses
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
Biological Activity
Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum antitumor activity. Phase 2.
in vivo
Voreloxin (20 mg/kg, i.v.) alone results in 80% reduction in bone marrow cellularity of CD-1 mice by administration one dose every 4 days repeated twice (q4d ×2). voreloxin at 10 mg/kg in combination with cytarabine causes ablation of the marrow, dilation of sinusoids, and infiltration of adipocytes in mice. Voreloxin (20 mg/kg, i.v.) combined with cytarabine causes a reversible decrease in myeloid and lymphoid cells in bone marrow and peripheral blood CD-1 mice. voreloxin (10 mg/kg, q4d ×2) and cytarabine in combination causes reversible neutropenia with a more modest impact on platelets CD-1 mice[2].
target
| Target | Value |
| Topo II |
IC 50
Topoisomerase II
References
[1] Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402. DOI:10.1517/14656566.2015.1044437
[2] Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. DOI:10.1007/s00280-009-1234-z
[3] Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96(3):393-9. DOI:10.3324/haematol.2010.032680
AG 7352 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 998 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4729 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
View Lastest Price from AG 7352 Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Voreloxin hydrochloride
175519-16-1
|
US $58.00-166.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. |
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- Voreloxin hydrochloride
175519-16-1
- US $58.00-166.00 / mg
- 99.85%
- TargetMol Chemicals Inc.