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3',4'-DiMethoxy-α-naphthoflavone

3',4'-DiMethoxy-α-naphthoflavone structure

CAS No.: 14756-24-2

Chemical Name:: 3',4'-DiMethoxy-α-naphthoflavone

Synonyms: DiMNF;NSC 123391;3',4'-DiMethoxy-α-naphthoflavone;3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-

CBNumber:: CB52653883

Molecular Formula:: C21H16O4

Molecular Weight:: 332.35

MDL Number:: MFCD00143008

MOL File:: 14756-24-2.mol

MSDS File:: SDS

Last updated:2023-05-19 08:29:27

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3',4'-DiMethoxy-α-naphthoflavone Properties

storage temp.	2-8°C
solubility	DMSO: ≥13mg/mL
form	powder
color	white to tan
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

3',4'-DiMethoxy-α-naphthoflavone price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0079	DiMNF ≥98% (HPLC)	14756-24-2	5mg	$206	2022-05-15	Buy
Usbiological	255150	DiMNF	14756-24-2	10mg	$432	2021-12-16	Buy
TRC	D461070	3'',4''-Dimethoxy-α-naphthoflavone	14756-24-2	25mg	$835	2021-12-16	Buy
Axon Medchem	Axon1935	DiMNF 99%	14756-24-2	10mg	$115.5	2021-12-16	Buy
Axon Medchem	Axon1935	DiMNF 99%	14756-24-2	2x50mg	$594	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML0079	5mg	$206	Buy
255150	10mg	$432	Buy
D461070	25mg	$835	Buy
Axon1935	10mg	$115.5	Buy
Axon1935	2x50mg	$594	Buy

3',4'-DiMethoxy-α-naphthoflavone Chemical Properties,Uses,Production

Description

DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3

Uses

3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

Uses

3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

References

1) Murray?et al. (2011),?Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;? Mol. Pharmacol.,?79?508 2) Narayanan?et al. (2012),?Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;? J. Pharmacol. Exp. Ther.,?342?345 3) Labrecque?et al. (2012),?Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;? PLoS One,?7(1)?e29545

3',4'-DiMethoxy-α-naphthoflavone synthesis

Synthesis of 3',4'-DiMethoxy-α-naphthoflavone from (E)-3-(3,4-dimethoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one

3',4'-DiMethoxy-α-naphthoflavone Preparation Products And Raw materials

Raw materials

(E)-3-(3,4-dimethoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one

Preparation Products

3',4'-DiMethoxy-α-naphthoflavone Suppliers

Global( 38)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94658	76
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8072	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29786	68
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	56086	58
BOC Sciences	--	info@bocsci.com	USA	0	65

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
sgtlifesciences pvt ltd	58
J & K SCIENTIFIC LTD.	76
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
BOC Sciences	65

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3',4'-DiMethoxy-α-naphthoflavone 2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one DiMNF NSC 123391 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one 4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)- 3',4'-DiMethoxy-α-naphthoflavone 14756-24-2 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals