AZD 2932
- CAS No.
- 883986-34-3
- Chemical Name:
- AZD 2932
- Synonyms
- CS-1792;AZD 2932;AGN-PC-00AQ5T;AZD 2932 USP/EP/BP;AZD 2932; AZD-2932; AGN-PC-00AQ5T;AZD2932;2-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide;Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-;2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide AZD2932;Platelet-derived growth factor receptor,Inhibitor,VEGFR,c-Kit,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,Vascular endothelial growth factor receptor,FLT3,SCFR,AZD-2932,AZD2932,inhibit,PDGFR,AZD 2932,CD117,CD135
- CBNumber:
- CB52667071
- Molecular Formula:
- C24H25N5O4
- Molecular Weight:
- 447.49
- MDL Number:
- MFCD25977021
- MOL File:
- 883986-34-3.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | crystalline solid |
| color | Light yellow to yellow |
| FDA UNII | SJ9PP5S9IM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
| NFPA 704 |
|
AZD 2932 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17741 | AZD 2932 ≥98% | 883986-34-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17741 | AZD 2932 ≥98% | 883986-34-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17741 | AZD 2932 ≥98% | 883986-34-3 | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 17741 | AZD 2932 ≥98% | 883986-34-3 | 25mg | $230 | 2024-03-01 | Buy |
| TRC | A808170 | AZD2932 | 883986-34-3 | 25mg | $125 | 2021-12-16 | Buy |
AZD 2932 Chemical Properties,Uses,Production
Uses
AZD2932 is a potent and multi-targeted protein tyrosine kinase inhibitor of VEFGR-2 and PDGFR.
Biological Activity
azd2932 is a potent inhibitor for multiple protein tyrosine kinases (ic50 = 8 nm, 4 nm, 7 nm, and 9 nm for vegfr-2, pdgfrβ, flt-3, and c-kit, respectively.) [1]vegfr are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases. it mediates in various cellular functions, including endothelial proliferation, migration, survival, tubular morphogenesis and sprouting. pdgfr are platelet-derived growth factor receptors that exhibit intracellular tyrosine kinase activity. it involves in embryonic development, angiogenesis, proliferation and differentiation etc.azd2932 has a potent and balanced profile against pdgfr, vegfr-2, flt-3 and c-kit (ic50: 0.009). it also has a good fraction unbound between 3.3% free in human and 7.0% in dog sera and has no activity against herg. [1]in female nude mice bearing c6 tumors, azd2932 treatment at 3–50 mg/kg b.i.d. 10 h apart give 60–80% inhibition of both p-vegfr-2 and p-pdgfrb in a 1:1 ratio. [1]
References
1. plé pa, jung f, ashton s, hennequin l et al. discovery of azd2932, a new quinazoline ether inhibitor with high affinity for vegfr-2 and pdgfr tyrosine kinases. bioorg med chem lett. 2012 jan 1;22(1):262-6.
AZD 2932 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
