ChemicalBook >> CAS DataBase List >>1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- structure

CAS No.: 911715-90-7

Chemical Name:: 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-

Synonyms: AZD 8797;KAND-567;KAN-0440567;AZD8797( KAND567);AZD 8797; AZD-8797;CX3CR1 antagonist 18a;AZD8797, 10 mM in DMSO;(R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4- METHYLPENTAN-1-OL;1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-;(R)-2-((2-Amino-5-(((S)-1-phenylethyl)thio)thiazolo[4,5-d]pyrimidin-7-yl)amino)-4-methylpentan-1-ol , AZD8797

CBNumber:: CB52668548

Molecular Formula:: C19H25N5OS2

Molecular Weight:: 403.56

MDL Number:: MFCD28139065

MOL File:: 911715-90-7.mol

Last updated:2025-04-17 18:22:24

Request For Quotation

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Properties

Boiling point	651.1±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 150 mg/mL (371.69 mM)
pka	14.47±0.10(Predicted)
form	Solid
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A632400	(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol	911715-90-7	1mg	$395	2021-12-16	Buy
ChemScene	CS-6469	AZD8797 98.65%	911715-90-7	10mg	$450	2021-12-16	Buy
ChemScene	CS-6469	AZD8797 98.65%	911715-90-7	25mg	$950	2021-12-16	Buy
ChemScene	CS-6469	AZD8797 98.65%	911715-90-7	50mg	$1500	2021-12-16	Buy
ChemScene	CS-6469	AZD8797 98.65%	911715-90-7	100mg	$2100	2021-12-16	Buy

Product number	Packaging	Price	Buy
A632400	1mg	$395	Buy
CS-6469	10mg	$450	Buy
CS-6469	25mg	$950	Buy
CS-6469	50mg	$1500	Buy
CS-6469	100mg	$2100	Buy

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Chemical Properties,Uses,Production

Uses

(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol is an allosteric non-competitive modulator of the human CX3CR1 receptor. It can be used to develop treatment for multiple sclerosis.

in vivo

AZD8797 treatment in Dark Agouti rats with myelin oligodendrocyte glycoprotein-induced EAE results in reduced paralysis, CNS pathology, and incidence of relapses. The compound is effective when starting treatment before onset, as well as after the acute phase^[2].

IC 50

CX3CR1: 3.9 nM (Ki, ¹²⁵I-CX3CL-CX3CR1 in HEK293S cells); ¹²⁵I-IL-8-CXCR2: 2800 nM (Ki, in HEK293S cells)

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Xingji Pharmaceutical (Shanghai) Co., Ltd	15705593425 15705593425	support@utgene.com	China	57	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Shanghai Synmedia Chemical Co., Ltd.	021-38681880 13817889927	sales@synmedia-chem.com	China	249	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4601	55

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Xingji Pharmaceutical (Shanghai) Co., Ltd	58
MedChemexpress LLC	58
Shanghai Synmedia Chemical Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55

View Lastest Price from 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-18	AZD8797 911715-90-7	US $83.00-372.00 / mg		99.68%	10g	TargetMol Chemicals Inc.
	2024-11-18	AZD8797 911715-90-7	US $83.00-372.00 / mg		99.68%	10g	TargetMol Chemicals Inc.

AZD8797
911715-90-7
US $83.00-372.00 / mg
99.68%
TargetMol Chemicals Inc.

AZD8797
911715-90-7
US $83.00-372.00 / mg
99.68%
TargetMol Chemicals Inc.

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- CX3CR1 antagonist 18a AZD 8797 (R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4- METHYLPENTAN-1-OL AZD 8797; AZD-8797 (2R)-2-[(2-amino-5-{[(1S)-1-phenylethyl]sulfanyl}-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol AZD8797( KAND567) (R)-2-((2-Amino-5-(((S)-1-phenylethyl)thio)thiazolo[4,5-d]pyrimidin-7-yl)amino)-4-methylpentan-1-ol , AZD8797 AZD8797, 10 mM in DMSO KAND-567 KAN-0440567 911715-90-7