ChemicalBook >> CAS DataBase List >>MK-4827 (tosylate)

MK-4827 (tosylate)

CAS No.
1038915-73-9
Chemical Name:
MK-4827 (tosylate)
Synonyms
Niraparib Tosylate;Niraparib TOS;Niraparib TsOH;MK-4827 (tosylate);Niraparib Tosilate;Niraparib(MK-4827) tosylate;MK-4827(Niraparib) tosylate;niraparib p-toluenesulfonate;MK-4827, Niraparib TsOH salt;Niraparib Tosylate (MK-4827)
CBNumber:
CB52682012
Molecular Formula:
C26H28N4O4S
Molecular Weight:
492.58992
MDL Number:
MFCD28167748
MOL File:
1038915-73-9.mol
Last updated:2024-11-19 15:53:33

MK-4827 (tosylate) Properties

Melting point >142oC (dec.)
storage temp. -20°C Freezer
solubility Methanol (Slightly)
form Solid
color Off-White to Pale Yellow
InChIKey LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|
FDA UNII 75KE12AY9U

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

MK-4827 (tosylate) price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20842 MK-4827 (tosylate) ≥98% 1038915-73-9 5mg $46 2024-03-01 Buy
Cayman Chemical 20842 MK-4827 (tosylate) ≥98% 1038915-73-9 50 mg $253 2024-03-01 Buy
Cayman Chemical 20842 MK-4827 (tosylate) ≥98% 1038915-73-9 1mg $32 2023-01-06 Buy
Cayman Chemical 20842 MK-4827 (tosylate) ≥98% 1038915-73-9 10mg $83 2024-03-01 Buy
Cayman Chemical 20842 MK-4827 (tosylate) ≥98% 1038915-73-9 25mg $149 2024-03-01 Buy
Product number Packaging Price Buy
20842 5mg $46 Buy
20842 50 mg $253 Buy
20842 1mg $32 Buy
20842 10mg $83 Buy
20842 25mg $149 Buy

MK-4827 (tosylate) Chemical Properties,Uses,Production

Description

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.

Uses

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

in vitro

In a whole-cell assay, Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC50=4 nM and EC90=45 nM. Niraparib tosylate hydrate inhibits the proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole-cell assay. Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment, reaching about 85% inhibition in the A549 cells at 1 h and about 55% inhibition at 1 h for the H1299 cells.

1038915-60-4
104-15-4
1038915-73-9
Synthesis of MK-4827 (tosylate) from Niraparib and p-Toluenesulfonic acid

MK-4827 (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 135)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266 market@hopelife.cn China 72 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 970 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32956 60
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597 sales04@yibaibiotech.com CHINA 419 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

Related articles

  • MK-4827 (tosylate)
  • To validate that MK-4827 (Niraparib) inhibits PARP in these cell lines, A549 and H1299 cells are treated with 1 μM MK-4827 for....
  • Aug 26,2019

View Lastest Price from MK-4827 (tosylate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK-4827 (tosylate) pictures 2024-12-24 MK-4827 (tosylate)
1038915-73-9
US $20.00 / kg 1kg 98% 2000kg hebei hongtan Biotechnology Co., Ltd
Niraparib tosylate pictures 2024-11-19 Niraparib tosylate
1038915-73-9
US $38.00-85.00 / mg 99.87% 10g TargetMol Chemicals Inc.
MK-4827 (tosylate) pictures 2024-08-27 MK-4827 (tosylate)
1038915-73-9
US $0.10-0.30 / kg 1kg 99% 20n tons Zibo Hangyu Biotechnology Development Co., Ltd
  • MK-4827 (tosylate) pictures
  • MK-4827 (tosylate)
    1038915-73-9
  • US $0.10-0.30 / kg
  • 99%
  • Zibo Hangyu Biotechnology Development Co., Ltd

MK-4827 (tosylate) Spectrum

Niraparib TsOH niraparib p-toluenesulfonate MK-4827(Niraparib) tosylate MK-4827 (tosylate) (3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate MK-4827, Niraparib TsOH salt Niraparib(MK-4827) tosylate NIRAPARIB TOSYLATE;MK 4827 TOSYLATE;MK4827 TOSYLATE 2H-Indazole-7-carboxamide,2-[4-[(3S)-3-piperidinyl]phenyl]-,4-methylbenzenesulfonate(1:1) Niraparib TOS MK-4827 (tosylate) ISO 9001:2015 REACH Niraparib Tosylate (MK-4827) Niraparib Tosylate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate Niraparib tosylate monohydrate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-isoindole-4-carboxamide compound with 1-methyl-4-(methylsulfonyl)benzene (1:1) hydrate Niraparib Tosilate 1038915-73-9 C19H20N4OC7H8O3S