(S)-b-AMino-4-Methoxy-benzeneethanol
- CAS No.
- 191109-48-5
- Chemical Name:
- (S)-b-AMino-4-Methoxy-benzeneethanol
- Synonyms
- (S)-p-hydroxyphenylglycinol;(S)-b-AMino-4-Methoxy-benzeneethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethan-1-ol;Benzeneethanol, β-amino-4-methoxy-, (βS)-;(2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL;(S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride
- CBNumber:
- CB52684223
- Molecular Formula:
- C9H13NO2
- Molecular Weight:
- 167.21
- MDL Number:
- MFCD09253728
- MOL File:
- 191109-48-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501 |
| HS Code | 2922500090 |
(S)-b-AMino-4-Methoxy-benzeneethanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0030554 | (2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL 95.00% | 191109-48-5 | 5MG | $505.77 | 2021-12-16 | Buy |
| Alichem | 191109485 | (S)-2-Amino-2-(4-methoxyphenyl)ethanol | 191109-48-5 | 1g | $539 | 2021-12-16 | Buy |
| Crysdot | CD12101137 | (S)-2-Amino-2-(4-methoxyphenyl)ethanol 95+% | 191109-48-5 | 1g | $607 | 2021-12-16 | Buy |
| Alichem | 191109485 | (S)-2-Amino-2-(4-methoxyphenyl)ethanol | 191109-48-5 | 5g | $960.4 | 2021-12-16 | Buy |
| Chemenu | CM279271 | (S)-2-Amino-2-(4-methoxyphenyl)ethanol 95% | 191109-48-5 | 5g | $1141 | 2021-12-16 | Buy |
(S)-b-AMino-4-Methoxy-benzeneethanol Chemical Properties,Uses,Production
Physical properties
A white crystal
Uses
(S)-2-Amino-2-(4-methoxyphenyl)ethanol hydrochloride is used as an intermediate in laboratory research.
Reactions
(S)-b-AMino-4-Methoxy-benzeneethanol could synthize oxidatively
cleavable chiral auxiliary-bearing tetramate derivative 1-[(S)-2-Hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-3-methyl-1H-pyrrol2(5H)-one with (E)-4-bromo-3-methoxy-2-methyl-2-butenoate. Due to its chirality, it can also be used to synthesize various chiral organics, such as 1-[(S) -2-hydroxy-1 -(4-methoxyphenyl)ethyl] -4-methoxy-3-methyl-1h-Pyrrol2 (5H)-one[1-2].
Synthesis
1.To an ice-cooled mixture of lithium borohydride (16.5 g, 759 mmol) in THF (270 mL) was added trimethylsilyl chloride (194 mL, 1.52 mol).
2.After stirring for 30 minutes, a mixture of (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (45.9 g, 253 mmol) in THF (1.00 L) was added dropwise to the reaction.
3.Then the reaction mixture was stirred at rt overnight.
4.The reaction was quenched with MeOH, and the resulting mixture was concentrated in vacuo.The residue was diluted with 1M sodium hydroxide aq.solution and chloroform, and filtered through a pad of Celite.
5.The filtrate was diluted with brine, and organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to give (S)-b-AMino-4-Methoxy-benzeneethanol (37.1 g) as red solids.
References
[1] Lan H, et al. The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. Chemical Communications, 2010; 46: 5319-532.
[2] Shemet A, et al. Total Synthesis of (?)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution. Organic Letters, 2017; 19: 5529–5532.
(S)-b-AMino-4-Methoxy-benzeneethanol Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-b-AMino-4-Methoxy-benzeneethanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Xinghan Biotechnology Co., Ltd | +8618698089028 | 1725517238@qq.com | China | 2479 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Tianjin Xinghan Biotechnology Co., Ltd | 13230698506 18698089028 | 1725517238@qq.com | China | 5009 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9906 | 55 |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 23337 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Shanghai CR Corporation Limited | 4006653949 | fred.wen@crcorporation.cn | China | 10066 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28819 | 58 |
| Mirro Chemical Co.,Ltd. | 0086-15313090952 | China | 2355 | 58 | |
| Aikon International Limited | 025-66028182 18112977050 | cfzhang@aikonchem.com | China | 15820 | 58 |