AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- CAS No.
- 6152-57-4
- Chemical Name:
- AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- Synonyms
- O-Methylviridicatin;Methylviridicatin, O-;3-methoxy-4-phenylquinolin-2(1H)-one;2(1H)-Quinolinone, 3-methoxy-4-phenyl-;AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- CBNumber:
- CB52703746
- Molecular Formula:
- C16H13NO2
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD14635391
- MOL File:
- 6152-57-4.mol
- MSDS File:
- SDS
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19446 | O-Methylviridicatin ≥99% | 6152-57-4 | 1mg | $163 | 2024-03-01 | Buy |
Cayman Chemical | 19446 | O-Methylviridicatin ≥99% | 6152-57-4 | 5mg | $608 | 2024-03-01 | Buy |
Usbiological | M3547-32 | O-Methylviridicatin | 6152-57-4 | 1mg | $426 | 2021-12-16 | Buy |
ApexBio Technology | C3069 | O-Methylviridicatin | 6152-57-4 | 5mg | $983 | 2021-12-16 | Buy |
ApexBio Technology | C3069 | O-Methylviridicatin | 6152-57-4 | 1mg | $263 | 2021-12-16 | Buy |
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Chemical Properties,Uses,Production
Uses
3-O-Methylviridicatin is a metabolite produced by several species of Penicillium. Recently, 3-O-methylviridicatin was shown to be a strong inhibitor of TNFα-induced replication of HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.
Biological Activity
5 μm: blocks activation of the hiv long terminal repeat by tnf-α in hela cellso-methylviridicatin, a natural derivative of the alkaloid mycotoxin viridicatin, is produced by several species in the genus, penicillium. it is demonstrated that o-methylviridicatin, as an inhibitor, blocks the tumor necrosis factor alpha (tnfα)-induced replication of human immunodeficiency virus (hiv). tnfα increases the binding of the cellular transcription factor nf-κb to the hiv long terminal repeat (ltr), which directly triggers transcription of the latent provirus.
in vitro
o-methylviridicatin had an inhibitory effect on the tnfα-triggered replication of hiv ltr in hela cells. in addition, o-methylviridicatin dose-dependently dampened virus production in the om-10.1 cell line, which was measured by the output of p24 core antigen into the culture medium. it was demonstrated that the suppressive effect of o-methylviridicatin was not reversed even if the concentration of tnfα was increased 10-fold [1].
IC 50
2.5 μm: inhibits virus production in om-10.1 cells (hl-60 promyelocytes infected with hiv-1) treated with tnf-α.
References
[1]. heguy, a., cai, p., meyn, p., houck, d., russo, s., & michitsch, r. et al. isolation and characterization of the fungal metabolite 3-o-methylviridicatin as an inhibitor of tumour necrosis factor-induced human immunodeficiency virus replication. antiviral chemistry and chemotherapy. 1998; 9(2): 149-155.
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8736 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |