Cerdulatinib HCl salt
- CAS No.
- 1369761-01-2
- Chemical Name:
- Cerdulatinib HCl salt
- Synonyms
- Cerdulatinib HCl;PRT2070 hydrochloride;Cerdulatinib HCl salt;PRT062070 hydrochloride;Cerdulatinib hydrochloride;Cerdulatinib HCl (PRT-2070;Cerdulatinib HCl salt USP/EP/BP;Cerdulatinib (PRT062070, PRT2070);Cerdulatinib|||PRT2070|||PRT062070 hydrochloride|||PRT062070|||PRT2070 hydrochloride;4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride
- CBNumber:
- CB52728651
- Molecular Formula:
- C20H28ClN7O3S
- Molecular Weight:
- 481.99942
- MDL Number:
- MFCD28348366
- MOL File:
- 1369761-01-2.mol
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
---|---|
solubility | DMSO:20.0(Max Conc. mg/mL);41.49(Max Conc. mM) |
form | Solid |
color | Light brown to brown |
FDA UNII | L1KRM66Y4X |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Cerdulatinib HCl salt price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0010193 | Cerdulatinib(hydrochloride) 99.54% | 1369761-01-2 | 5mg | $108 | 2021-12-16 | Buy |
ChemScene | CS-0010193 | Cerdulatinib(hydrochloride) 99.54% | 1369761-01-2 | 10mg | $144 | 2021-12-16 | Buy |
ChemScene | CS-0010193 | Cerdulatinib(hydrochloride) 99.54% | 1369761-01-2 | 50mg | $480 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0002513 | 4-(CYCLOPROPYLAMINO)-2-[[4-[4-(ETHYLSULFONYL)-1-PIPERAZINYL]PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE HYDROCHLORIDE 95.00% | 1369761-01-2 | 5MG | $500.01 | 2021-12-16 | Buy |
ChemScene | CS-0010193 | Cerdulatinib(hydrochloride) 99.54% | 1369761-01-2 | 100mg | $744 | 2021-12-16 | Buy |
Cerdulatinib HCl salt Chemical Properties,Uses,Production
Biological Activity
Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.
in vitro
Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.
in vivo
In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.
target
Target | Value |
TYK2 (Cell-free assay) | 0.5 nM |
MST1 (Cell-free assay) | 4 nM |
4 nM | |
MLK1 (Cell-free assay) td> | 5 nM |
Fms (Cell-free assay) | 5 nM |
Cerdulatinib HCl salt Preparation Products And Raw materials
Raw materials
Preparation Products
Cerdulatinib HCl salt Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24407 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |