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ChemicalBook >> CAS DataBase List >>N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Structure
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride structure
CAS No.
1373232-26-8
Chemical Name:
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride
Synonyms
Cl-Amidine (hydrochloride);N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride;Cl-Amidine (hydrochloride) - Sold under license from the University of South Carolina under U.S. Patent No. 7,964,363;Cl amidine hydrochloride,miRNA-16,Protein Arginine Deiminase,Cl-amidine,inhibit,MicroRNA,Peptidylarginine Deiminase,Clamidine hydrochloride,Inhibitor,miRNA,microRNA-16,colitis,sepsis,Apoptosis,miR-16
CBNumber:
CB52746936
Molecular Formula:
C14H20Cl2N4O2
Molecular Weight:
347.2402
MDL Number:
MFCD22201084
MOL File:
1373232-26-8.mol
Last updated:2024-11-11 20:33:26
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N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Properties

storage temp. Store at -20°C
solubility DMF: 14 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 3 mg/ml
form A crystalline solid
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
NFPA 704
0
2 0

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10599 Cl-Amidine (hydrochloride) 1373232-26-8 1mg $49 2024-03-01 Buy
Cayman Chemical 10599 Cl-Amidine (hydrochloride) 1373232-26-8 10mg $221 2024-03-01 Buy
Cayman Chemical 10599 Cl-Amidine (hydrochloride) 1373232-26-8 5mg $147 2024-03-01 Buy
TRC A794960 N-[(1s)-1-(Aminocarbonyl)-4-[(2-Chloro-1-Iminoethyl)Amino]Butyl]-BenzamideHydrochloride 1373232-26-8 2mg $65 2021-12-16 Buy
ChemScene CS-0019715 Cl-amidine(hydrochloride) 1373232-26-8 10mg $190 2021-12-16 Buy
Product number Packaging Price Buy
10599 1mg $49 Buy
10599 10mg $221 Buy
10599 5mg $147 Buy
A794960 2mg $65 Buy
CS-0019715 10mg $190 Buy

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Chemical Properties,Uses,Production

Description

Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs; IC50s = 0.8, 6.2, and 5.9 μM for PAD1, PAD3, and PAD4, respectively). It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively). Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil extracellular trap (NET) formation and increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP). It also decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis in a dose-dependent manner.

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32076 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38468 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1460 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 meilunui@163.com China 4727 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4456 55
JW & Y Pharmlab Co., Ltd. 021-64340559 13651849907; xinyu_shi@jwypharmlab.com.cn China 12036 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8012 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 Sales@ATKchemical.com China 7045 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Chemtour Biotech Co., Ltd 		58
Aladdin Scientific 		58
Dalian Meilun Biotech Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
JW & Y Pharmlab Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58

View Lastest Price from N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cl-amidine hydrochloride pictures 2024-11-11 Cl-amidine hydrochloride
1373232-26-8
 US $37.00-147.00 / mg 98.14% 10g TargetMol Chemicals Inc.
Cl-amidine hydrochloride pictures 2024-11-11 Cl-amidine hydrochloride
1373232-26-8
 US $37.00-147.00 / mg 98.14% 10g TargetMol Chemicals Inc.
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Cl-Amidine (hydrochloride) Cl-Amidine (hydrochloride) - Sold under license from the University of South Carolina under U.S. Patent No. 7,964,363 Cl amidine hydrochloride,miRNA-16,Protein Arginine Deiminase,Cl-amidine,inhibit,MicroRNA,Peptidylarginine Deiminase,Clamidine hydrochloride,Inhibitor,miRNA,microRNA-16,colitis,sepsis,Apoptosis,miR-16 1373232-26-8