2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
![2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Structure](CAS/20180703/GIF/313669-88-4.gif)
- CAS No.
- 313669-88-4
- Chemical Name:
- 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
- Synonyms
- BMS-986122;BMS-986122 >=98% (HPLC);BMS-986122, 10 mM in DMSO;2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine;Thiazolidine, 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-;positive,BMS986122,modulator,allosteric,recruitment,β-arrestin,adenylyl,Opioid Receptor,BMS-986122,inhibit,cyclase,Inhibitor,protein
- CBNumber:
- CB52750513
- Molecular Formula:
- C16H15BrClNO3S2
- Molecular Weight:
- 448.78
- MDL Number:
- MFCD00825276
- MOL File:
- 313669-88-4.mol
- MSDS File:
- SDS
| Boiling point | 567.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.586±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | -8.81±0.40(Predicted) |
| form | powder |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0917 | BMS-986122 ≥98% (HPLC) | 313669-88-4 | 5mg | $140 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0917 | BMS-986122 ≥98% (HPLC) | 313669-88-4 | 25mg | $537 | 2024-03-01 | Buy |
| Cayman Chemical | 23269 | BMS 986122 ≥98% | 313669-88-4 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 23269 | BMS 986122 ≥98% | 313669-88-4 | 5mg | $227 | 2024-03-01 | Buy |
| AK Scientific | 0461CN | 2-(3-Bromo-4-methoxyphenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine | 313669-88-4 | 1mg | $152 | 2021-12-16 | Buy |
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Chemical Properties,Uses,Production
Uses
BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2].
Biochem/physiol Actions
BMS-986122 may exhibit an antinociception effect in vivo by increasing the efficiency of Met-enkephalin (met-Enk) to inhibit γ aminobutyric acid (GABA) release in the periaqueductal gray region of the brain.
IC 50
μ Opioid Receptor/MOR
References
[1] Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. DOI:10.1073/pnas.1300393110
[2] Kandasamy R, et al. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proc Natl Acad Sci U S A. 2021;118(16):e2000017118. DOI:10.1073/pnas.2000017118
[3] Livingston KE, Alt A, Canals M, Traynor JR. Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Mol Pharmacol. 2018;93(2):157-167. DOI:10.1124/mol.117.109561
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6188 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29763 | 68 |