2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
![2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Structure](CAS/GIF/316130-82-2.gif)
- CAS No.
- 316130-82-2
- Chemical Name:
- 2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
- Synonyms
- RSVA314;AMPK Activator VI, RSVA314;AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem;2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide;Benzoic acid, 2-hydroxy-, 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide
- CBNumber:
- CB52750689
- Molecular Formula:
- C18H21N3O3
- Molecular Weight:
- 327.38
- MDL Number:
- MFCD00556745
- MOL File:
- 316130-82-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H400 |
| Precautionary statements | P261-P273-P305+P351+P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36/37/38-50 |
| Safety Statements | 26-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 171272 | AMPK Activator VI, RSVA314 | 316130-82-2 | 10mg | $155 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0779 | RSVA314 ≥98% (HPLC) | 316130-82-2 | 5mg | $83.4 | 2022-05-15 | Buy |
| Matrix Scientific | 059696 | N'-[4-(Diethylamino)-2-hydroxybenzylidene]-2-hydroxybenzohydrazide | 316130-82-2 | 500mg | $199 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM1035576 | BENZOIC ACID, 2-HYDROXY-, [[4-(DIETHYLAMINO)-2-HYDROXYPHENYL]METHYLENE]HYDRAZIDE 95.00% | 316130-82-2 | 5MG | $500.31 | 2021-12-16 | Buy |
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Chemical Properties,Uses,Production
General Description
A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 μM. Treatment with RSVA314 at 1-3 μM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.
Biochem/physiol Actions
RSVA314 is a resveratrol analog that is a potent indirect activator of AMPK (AMP-activated protein kinase). RSVA314 is a potent inhibitor of adipogenesis in vitro in cultured cells and in vivo in mice. Apparently RSVA314 activates AMPK via a mechanism implicating CaMKKβ and LKB1. Also RSVA314 increases intracellular clearance of the amyloidogenic peptide Aβ, the core component of the amyloid plaques.
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxy-benzoic acid 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |