ChemicalBook >> CAS DataBase List >>N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
- CAS No.
- 1401089-31-3
- Chemical Name:
- N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
- Synonyms
- PACMA 31;PACMA 31 >=98% (HPLC);N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester;Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester;bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent
- CBNumber:
- CB52750694
- Molecular Formula:
- C21H22N2O6S
- Molecular Weight:
- 430.47
- MDL Number:
- MFCD26793891
- MOL File:
- 1401089-31-3.mol
- MSDS File:
- SDS
Last updated:2023-09-04 15:50:00
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0838 | PACMA 31 ≥98% (HPLC) | 1401089-31-3 | 5mg | $127 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0838 | PACMA 31 ≥98% (HPLC) | 1401089-31-3 | 25mg | $482 | 2024-03-01 | Buy |
Tocris | 5116 | PACMA 31 ≥99%(HPLC) | 1401089-31-3 | 10 | $87 | 2021-12-16 | Buy |
TRC | P132083 | PACMA 31 | 1401089-31-3 | 1mg | $60 | 2021-12-16 | Buy |
TRC | P132083 | PACMA 31 | 1401089-31-3 | 5mg | $235 | 2021-12-16 | Buy |
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Chemical Properties,Uses,Production
Uses
PACMA 31 is a protein disulfide isomerase family A member 1 (PDIA1) inhibitor as promising target for chemotherapy.
Biochem/physiol Actions
PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model.
storage
Store at RT
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Suppliers
Global( 32)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3732 | 55 |
Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Supplier | Advantage |
---|---|
Career Henan Chemica Co | 58 |
Aladdin Scientific | 58 |
ChemeGen 中国 | 58 |
Sigma-Aldrich | 80 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 55 |
Shanghai Han-Xiang Chemical Co., Ltd. | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 58 |
BOC Sciences | 65 |
DC Chemicals | 58 |
Energy Chemical | 58 |
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
PACMA 31
Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester
PACMA 31 >=98% (HPLC)
bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent
1401089-31-3