Anti-hKFC-B antibody produced in rabbit

Biological Activity

TAOK1 (thousand-and-one amino acid kinase 1) gene encodes a serine/threonine-protein kinase th at phosphorylates MAP/ERK kinases (MEKs) 3 and 6 and activates p38 mitogen-activated protein (MAP) kinase cascades. This protein is a member of the Sterile-20 or Ste20 family of kinases with an N-terminal kinase domain. It mediates the activation of p38 in response to genotoxic stress or DNA damage caused by ionizing radiation, ultraviolet radiation, and hydroxyurea. It lacks a microtubule-binding site and activates c-Jun N-terminal kinase (JNK). It induces apoptotic morphological changes, such as cell contraction, membrane blebbing, and apoptotic body formation. It is also involved in the phosphorylation and cleavage of Rho kinase-1 (ROCK-I), which in turn induces TAOK1 to promote cell contraction and membrane blebbing.