ChemicalBook >> CAS DataBase List >>Benidipine hydrochloride
Benidipine hydrochloride
- CAS No.
- 91599-74-5
- Chemical Name:
- Benidipine hydrochloride
- Synonyms
- (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;(R,R)(S,S)-Benidipine Hydrochloride
- CBNumber:
- CB5294563
- Molecular Formula:
- C28H31N3O6.HCl
- Molecular Weight:
- 542.02
- MDL Number:
- MFCD00906929
- MOL File:
- 91599-74-5.mol
Last updated:2024-11-19 23:02:33
| Melting point | 199-201°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 7.34(at 25℃) |
| form | powder |
| color | yellow |
| InChIKey | DGVVISBYHUXFIU-UHFFFAOYSA-N |
| CAS DataBase Reference | 91599-74-5(CAS DataBase Reference) |
| FDA UNII | 0A6746FWDL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7975657 | |||||||||
| HS Code | 2933.99.5300 | |||||||||
| Toxicity | LD50 orally in male mice: 218 mg/kg (Muto, 1988) | |||||||||
| NFPA 704 |
|
Benidipine hydrochloride price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B6813 | Benidipine hydrochloride ≥98% (HPLC) | 91599-74-5 | 10mg | $91.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | B6813 | Benidipine hydrochloride ≥98% (HPLC) | 91599-74-5 | 50mg | $354 | 2024-03-01 | Buy |
| TCI Chemical | B5629 | Benidipine Hydrochloride | 91599-74-5 | 100MG | $26 | 2024-03-01 | Buy |
| TCI Chemical | B5629 | Benidipine Hydrochloride | 91599-74-5 | 1G | $237 | 2024-03-01 | Buy |
| Cayman Chemical | 21607 | Benidipine (hydrochloride) ≥98% | 91599-74-5 | 10mg | $37 | 2024-03-01 | Buy |
Benidipine hydrochloride Chemical Properties,Uses,Production
Description
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.
Description
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.
Chemical Properties
Yellow Crystalline Powder
Originator
Kyowa Hakko (Japan)
Uses
A dihydropyridine calcium channel blocker. Antihypertensive.
brand name
Coniel
Biological Activity
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
Safety Profile
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
storage
room temperature (desiccate)
Benidipine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 280)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10032 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from Benidipine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Benidipine hydrochloride
91599-74-5
|
US $30.00-40.00 / mg | 99.56% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-14 | Benidipine hydrochloride
91599-74-5
|
US $1050.00 / g/Bag | 100g | 99% | 10kg | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2021-07-09 | Benidipine hydrochloride
91599-74-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Benidipine hydrochloride
91599-74-5
- US $30.00-40.00 / mg
- 99.56%
- TargetMol Chemicals Inc.
-
- Benidipine hydrochloride
91599-74-5
- US $1050.00 / g/Bag
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- Benidipine hydrochloride
91599-74-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
91599-74-5(Benidipine hydrochloride)Related Search:
(R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT
Coniel, Capadipine, KW-3049, Nacadipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-
(R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride
Benidipine hydrochloride
monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste
1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE
2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate
(R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny
Benidipine hydrochlo
(4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)
(4R)-rel-3,5-Pyridinedicarboxylic acid
3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester
Conipros
rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride
(4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride
rac Benidipine Hydrochloride
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-
rac-Benidipine HCl
Benidipine Impurity 4
3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
Benidipine hydrochloride USP/EP/BP
(R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride
(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
Benidipin
(R,R)(S,S)-Benidipine Hydrochloride
(±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride
(3R*)-1-Benzylpiperidin-3-yl methyl (4R*)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Cocaine Hydrochloride Impurity 3(Cocaine Hydrochloride EP Impurity C )(β-Truxilline)
91599-74-5
91599-47-5
C28H32ClN3O6
C28H31N3O6
Inhibitors
Antihypertensive
Intermediates & Fine Chemicals
Pharmaceuticals
Aromatics
Chiral Reagents
Heterocycles