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CDKI-73

CDKI-73 structure

CAS No.: 1421693-22-2

Chemical Name:: CDKI-73

Synonyms: CS-2259;CDKI-73;asnuciclib;CDKI-73 (CDKI73);Asnuciclib (CDKI-73);CDKI-73, 10 mM in DMSO;3-((5-Fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)benzenesulfonamide;3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide;Benzenesulfonamide, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-;toxicity,Inhibitor,low,AML,Acute,LS 007,myeloid,LS007,leukemia,CLL,Apoptosis,LS-007,endosome,Cyclin dependent kinase,CDKI73,CDKI-73,CDKI 73,inhibit,CDK

CBNumber:: CB53034461

Molecular Formula:: C15H15FN6O2S2

Molecular Weight:: 394.45

MDL Number:: MFCD28386217

MOL File:: 1421693-22-2.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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CDKI-73 Properties

Boiling point	642.9±65.0 °C(Predicted)
Density	1.524±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:52.0(Max Conc. mg/mL);131.83(Max Conc. mM)
form	Solid
pka	10.06±0.60(Predicted)
color	Light yellow to yellow
FDA UNII	235XBY3N9F

CDKI-73 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-3953	CDKI-73 99.58%	1421693-22-2	5mg	$420	2021-12-16	Buy
ChemScene	CS-3953	CDKI-73 99.58%	1421693-22-2	10mg	$600	2021-12-16	Buy
Biorbyt Ltd	orb611582	CDKI-73	1421693-22-2	100mg	$1060.8	2021-12-16	Buy
ChemScene	CS-3953	CDKI-73 99.58%	1421693-22-2	50mg	$1800	2021-12-16	Buy
Biorbyt Ltd	orb611582	CDKI-73	1421693-22-2	250mg	$2097.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-3953	5mg	$420	Buy
CS-3953	10mg	$600	Buy
orb611582	100mg	$1060.8	Buy
CS-3953	50mg	$1800	Buy
orb611582	250mg	$2097.8	Buy

CDKI-73 Chemical Properties,Uses,Production

Uses

3-[[5-Fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]benzenesulfonamide is a potent CDK inhibitor. A highly efficacious CDK9 inhibitor against acute myeloid leukemia.

in vivo

Asnuciclib (25, 50, 100 mg/kg) markedly decreases tumor growth in a dose-dependent manner and results in a prolongation of animal life span (P < 0.001) without causing body weight loss and other overt toxicities.^[3].

Animal Model:	MV4-11 tumor bearing mice^[3].
Dosage:	25 mg/kg.
Administration:	Orally once everyday for 33 days.
Result:	Caused a remarkable delay in tumor growth compared to vehicle-treated mice, as reflected in a percentage for the mean tumor volume in treated to control mice of 43% at day 31.

Animal Model:	Balb/C mice aged 6-8 weeks^[3].
Dosage:	2 mg/kg (IV), 10, 20 and 40 mg/kg (PO). (Pharmacokinetic Analysis.)
Administration:	IV and PO, single dose.
Result:	The C_max increased from 1.29 to 3.66 μM at a mean time of 1 h and the area under the curve (AUC) of CDKI-73 increased from 3.51 to 12.8 μM.h when the oral dose was escalated from 10 to 40 mg/kg. CDKI-73 was eliminated from plasma with a mean terminal half-life (T1/2) of 2 h. Its oral bioavailability (F) ranged from 54 to 85% across the three doses.

IC 50

CDK2: 3.27 nM (IC₅₀); CDK9: 5.78 nM (IC₅₀); CDK1: 8.17 nM (IC₅₀); CDK4: 8.18 nM (IC₅₀); CDK6: 37.68 nM (IC₅₀); CDK7: 134.26 nM (IC₅₀); CDK1: 4 nM (Ki); CDK2: 3 nM (Ki); CDK9: 4 nM (Ki); CDK7: 91 nM (Ki)

CDKI-73 Preparation Products And Raw materials

Raw materials

Preparation Products

CDKI-73 Suppliers

Global( 64)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38636	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
BOC Sciences	65

View Lastest Price from CDKI-73 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-27	CDKI-73 1421693-22-2	US $146.00-443.00 / mg		98.11%	10g	TargetMol Chemicals Inc.
	2024-11-18	CDKI-73 1421693-22-2	US $146.00-308.00 / mg		98.11%	10g	TargetMol Chemicals Inc.

CDKI-73
1421693-22-2
US $146.00-443.00 / mg
98.11%
TargetMol Chemicals Inc.

CDKI-73
1421693-22-2
US $146.00-308.00 / mg
98.11%
TargetMol Chemicals Inc.

CDKI-73 Benzenesulfonamide, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]- CDKI-73 (CDKI73) CS-2259 asnuciclib toxicity,Inhibitor,low,AML,Acute,LS 007,myeloid,LS007,leukemia,CLL,Apoptosis,LS-007,endosome,Cyclin dependent kinase,CDKI73,CDKI-73,CDKI 73,inhibit,CDK 3-((5-Fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)benzenesulfonamide 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide CDKI-73, 10 mM in DMSO Asnuciclib (CDKI-73) 1421693-22-2 C15H15FN6O2S2