Nervonic acid
- CAS No.
- 506-37-6
- Chemical Name:
- Nervonic acid
- Synonyms
- tetracosenic acid;15-TETRACOSENOIC ACID;CIS-15-TETRACOSENOIC ACID;SELACHOLEIC ACID;(Z)-Tetracos-15-enoic acid;selacholeic;cis-15-Teracosenoic acid;neuro acid;Neural acid;Nervonic aci
- CBNumber:
- CB5304545
- Molecular Formula:
- C24H46O2
- Molecular Weight:
- 366.62
- MDL Number:
- MFCD00010507
- MOL File:
- 506-37-6.mol
- MSDS File:
- SDS
| Melting point | 42-43 °C (lit.) |
|---|---|
| Boiling point | 459.84°C (rough estimate) |
| Density | 0.9009 (rough estimate) |
| refractive index | 1.4806 (estimate) |
| Flash point | >230 °F |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Hexanes (Very Slightly) |
| form | Liquid |
| pka | 4.78±0.10(Predicted) |
| color | White to Pale Yellow |
| biological source | plant |
| BRN | 1728551 |
| InChI | InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9- |
| InChIKey | GWHCXVQVJPWHRF-KTKRTIGZSA-N |
| SMILES | C(O)(=O)CCCCCCCCCCCCC/C=C\CCCCCCCC |
| LogP | 10.890 (est) |
| CAS DataBase Reference | 506-37-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 91OQS788BE |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 2916.19.3000 | |||||||||
| NFPA 704 |
|
Nervonic acid price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 87117 | Nervonic acid analytical standard | 506-37-6 | 100mg | $147 | 2024-03-01 | Buy |
| TCI Chemical | T1642 | cis-15-Tetracosenoic Acid >95.0%(GC) | 506-37-6 | 1g | $319 | 2024-03-01 | Buy |
| Cayman Chemical | 13940 | Nervonic Acid ≥95% | 506-37-6 | 100mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 13940 | Nervonic Acid ≥95% | 506-37-6 | 250mg | $92 | 2024-03-01 | Buy |
| Sigma-Aldrich | N1514 | Nervonic acid ≥99% (capillary GC) | 506-37-6 | 100mg | $78.5 | 2024-03-01 | Buy |
Nervonic acid Chemical Properties,Uses,Production
Description
Nervonic acid, also known as shark oil acid, is a monounsaturated omega-9 fatty acid that exists in nerve tissue and fish oil. It was first discovered in shark brain and is a component of cerebroside, the main source of in shark brain and shark oil. It is also found in the sphingolipids of white matter in human brain. It is the only dual-action miracle substance that can repair nerve fibers that unblock damaged nerve pathways in the brain and promote nerve cell regeneration. Nervonic acid has been identified as important in the biosynthesis of nerve cell myelin. It is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids.
Occurrence
Nervonic acid is abundant in King Salmon ( Chinook ) with 140 mg/100g, yellow mustard seed 83 mg/100g , flax seed 64 mg/ 100g, Sockeye salmon 40 mg/100g, sesame seed 35mg/100g, and macademia nuts 18 mg/100g.
Uses
Found in sphingolipids of the white matter of the human brain, neuronic acid is the only magical substance with a dual role in brain development, repairing nerve fibers, unblocking damaged neural pathways in the brain, and promoting nerve cell regeneration. Neuroic acid is very important in the biosynthesis of nerve cell myelin, which together with lignoceric acid accounts for 60% of the acylated fatty acids in white matter sphingomyelin. In demyelinating diseases such as adrenoleukodystrophy and multiple sclerosis, the amount of neuronic acid acylated to sphingolipids is highly reduced, and supplements rich in this fatty acid have been used to help treat these demyelinating diseases.
Definition
ChEBI: Nervonic Acid is a monounsaturated fatty acid with a 24-carbon backbone and the sole double bond originating from the 9th carbon from the methyl end, with this bond in the cis- configuration. It is a metabolite found in the aging mouse brain.
Preparation
Nervonic acid was shown to be identical with selachaleic acid isolated from whale oils. It is obvious that nervonic acid is probably the cis form of erucylacetic acid. Erucylacetic acid has been prepared from erucyl alcohol through the bromide and malonic ester synthesis and has been shown to be identical with nervonic acid obtained from hydrolysis of the cerebroside isolated from human brains.
Nervonic acid is also produced from oleic acid, that undergoes three consecutive chain elongation steps, catalyzed by elongases.Two carbon units are added in each step, with production of gadoleic acid, erucic acid, and finally, nervonic acid.
benefits
Nervonic acid (NA, a monounsaturated long-chain fatty acid) has been found to alleviate neurodegeneration. In humans, abnormal NA levels are closely associated with a higher risk of developing neurological or psychiatric disorders such as psychosis, schizophrenia, or attention deficit disorder. Studies have shown that NA treatment can improve cognitive function, prevent demyelination and oligodendrocyte loss or apoptosis, improve cerebral blood flow, and upregulate brain-derived neurotrophic factor and myelin basic protein genes. In addition, NA can not only stimulate adipogenesis by regulating signaling pathways in human MSCs, but also improve the results of fat transplantation by reducing inflammation and stimulating angiogenesis.
General Description
Nervonic acids are the products of desaturation and elongation processes of various fatty acids such as palmitic acid, stearic acid, oleic acid, etc.
Biochem/physiol Actions
Nervonic acid (C24:1), a component of membrane sphingolipids and phosphatidylethanolamines, may be a useful predictor of chronic kidney disease mortality and diabetes. Nervonic acid oils are being studied for pharmaceutical, nutraceutical and industrial applications. Nervonic acid is a major component of Lunaria oil.
Source
Sources of Nervonic acid include oil crop seeds, oil-producing microalgae and other microorganisms. Transgenic technology can also be used to improve the source and production of Nervonic acid.
Nervonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shangdong Yuanlitai Nutratech Co.,ltd | +8618782242822 | tatiana@yltnutra.com | China | 8 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2608 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 430 | 58 |
| S&Y Biochem Co.,Ltd | +8617774091612 | marketing@sybiochem.com | China | 128 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8805 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 900 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3007 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
Related articles
- Nervonic acid: Source and Benefits
- Nervonic acid (C24:1 Δ15, cis-15-tetracosenoic acid, NA) is a very long-chain fatty acid whose name originated from the origin....
- Dec 19，2024
View Lastest Price from Nervonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-08 | Nervonic Acid
506-37-6
|
US $0.00 / KG | 2KG | 90% up | 20 tons | Sinoway Industrial co., ltd. | |
 |
2025-02-08 | Nervonic acid
506-37-6
|
US $20.00 / kg | 1kg | 99% | 5000kg/Week | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-01-31 | Nervonic Acid
506-37-6
|
US $0.00-0.00 / g | 10g | 99% HPLC | 10000 | HangZhou RunYan Pharma Technology Co.,LTD. |
-
- Nervonic Acid
506-37-6
- US $0.00 / KG
- 90% up
- Sinoway Industrial co., ltd.
-
- Nervonic acid
506-37-6
- US $20.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Nervonic Acid
506-37-6
- US $0.00-0.00 / g
- 99% HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
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