DASA-58
- CAS No.
- 1203494-49-8
- Chemical Name:
- DASA-58
- Synonyms
- CS-1563;DASA-58;DASA58; DASA 58;3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine;Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-;DASA58,inhibit,Inhibitor,DASA 58,DASA-58,glycolysis,TXNIP,cancer metabolism,Pyruvate Kinase,pyruvate kinase M2,breast cancer,AMPK
- CBNumber:
- CB53049409
- Molecular Formula:
- C19H23N3O6S2
- Molecular Weight:
- 453.53
- MDL Number:
- MFCD29472280
- MOL File:
- 1203494-49-8.mol
| Boiling point | 681.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.453±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥127.2 mg/mL in DMSO |
| form | solid |
| pka | 3.35±0.10(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
DASA-58 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2853 | DASA-58 ≥98% (HPLC) | 1203494-49-8 | 5MG | $94.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2853 | DASA-58 ≥98% (HPLC) | 1203494-49-8 | 25MG | $306 | 2024-03-01 | Buy |
| Cayman Chemical | 13941 | DASA-58 ≥98% | 1203494-49-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 13941 | DASA-58 ≥98% | 1203494-49-8 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 13941 | DASA-58 ≥98% | 1203494-49-8 | 10mg | $321 | 2024-03-01 | Buy |
DASA-58 Chemical Properties,Uses,Production
Description
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.
Definition
ChEBI: 3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline is a member of benzenes and a sulfonamide.
References
[1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nature chemical biology, 2012, 8(10): 839-847.
DASA-58 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
