3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide
- CAS No.
- 354812-16-1
- Chemical Name:
- 3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide
- Synonyms
- AA43279, CID 4278270;3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide;2-Thiophenecarboxamide, 3-amino-5-(4-methoxyphenyl)-;3-Amino-5-(4-Methoxyphenyl)-2-Thiophenecarboxamide(WXC03635)
- CBNumber:
- CB53096216
- Molecular Formula:
- C12H12N2O2S
- Molecular Weight:
- 248.3
- MDL Number:
- MFCD00277422
- MOL File:
- 354812-16-1.mol
Last updated:2023-04-23 13:52:06
| Boiling point | 456.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.312±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 35 mg/ml) |
| form | solid |
| pka | 15.71±0.50(Predicted) |
| color | Tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Arctom | AS031552 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide | 354812-16-1 | 1g | $425 | 2021-12-16 | Buy |
| Crysdot | CD11137088 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide 95+% | 354812-16-1 | 1g | $446 | 2021-12-16 | Buy |
| Chemenu | CM323957 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide 95% | 354812-16-1 | 1g | $458 | 2021-12-16 | Buy |
| Crysdot | CD11137088 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide 95+% | 354812-16-1 | 5g | $1340 | 2021-12-16 | Buy |
| Chemenu | CM323957 | 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide 95% | 354812-16-1 | 5g | $1384 | 2021-12-16 | Buy |
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide Chemical Properties,Uses,Production
Description
AA43279 (354812-16-1) is a selective Nav1.1 activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal brain slices it increased the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1
References
1) Frederiksen et al. (2017), A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.; Eur. J. Neuroscience, 46 1887
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide Suppliers
Global( 19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Aikon International Limited | 025-66113011 18112977050 | sales01@aikonchem.com | China | 16028 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3670 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
354812-16-1(3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide)Related Search:
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide
AA43279, CID 4278270
3-Amino-5-(4-Methoxyphenyl)-2-Thiophenecarboxamide(WXC03635)
2-Thiophenecarboxamide, 3-amino-5-(4-methoxyphenyl)-
354812-16-1