HLCL-61 (hydrochloride)
- CAS No.
- 1158279-20-9
- Chemical Name:
- HLCL-61 (hydrochloride)
- Synonyms
- CS-2798;HLCL-61.HCl;HLCL61;HLCL 61;HLCL-61 (hydrochloride);HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
- CBNumber:
- CB53122928
- Molecular Formula:
- C23H25ClN2O
- Molecular Weight:
- 380.92
- MDL Number:
- MFCD09446681
- MOL File:
- 1158279-20-9.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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HLCL-61 (hydrochloride) price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19897 | HLCL-61 (hydrochloride) ≥98% | 1158279-20-9 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 19897 | HLCL-61 (hydrochloride) ≥98% | 1158279-20-9 | 5mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 19897 | HLCL-61 (hydrochloride) ≥98% | 1158279-20-9 | 10mg | $172 | 2024-03-01 | Buy |
Cayman Chemical | 19897 | HLCL-61 (hydrochloride) ≥98% | 1158279-20-9 | 25mg | $321 | 2024-03-01 | Buy |
ChemScene | CS-5600 | HLCL-61(hydrochloride) 99.98% | 1158279-20-9 | 100mg | $540 | 2021-12-16 | Buy |
HLCL-61 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
hlcl-61 is a prmt5 inhibitor.aberrant methylation of protein arginine residues mediated by protein arginine methyltransferase (prmt) enzymes is reported to be linked to cancer. prmts are a family of proteins with 11 known members catalyzing the transfer of methyl group(s) to the guanidine nitrogen atoms of peptide arginine residues. prmt5 has multiple substrates including histones and other non-chromatin proteins and has been gained attention for cancer therapy.
in vitro
in previous study, hlcl-61 showed no inhibitory activity against prmt1, prmt4, and type ii prmt family members, therefore demonstrating its specificity for prmt5. hlcl-61 also showed effective inhibition of symmetric arginine dimethylation of histones h3 and h4, starting at 12 h posttreatment and persisting for 48 h. moreover, the treatment of aml cell lines and primary blasts with hlcl-61 led to the decrease of cell viability. in addition, hlcl-61-treated aml cell lines and patient samples had induction of differentiation as demonstrated by dose-dependent increases in the expression of cd11b. furthermore, prmt5 inhibition caused by hlcl-61 treatment led to a decrease in mv4-11 cells [1].
target
Protein arginine methyltransferase 5
References
[1] tarighat ss et al. the dual epigenetic role of prmt5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. leukemia. 2016 apr;30(4):789-99.
HLCL-61 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4197 | 55 |