Lu AF21934
- CAS No.
- 1445605-23-1
- Chemical Name:
- Lu AF21934
- Synonyms
- CS-2215;Lu AF21934;LuAF21934, >98%;LU-AF 21934;LU AF 21934;LU AF-21934;LU AF 21934;LU-AF21934;LU-AF-21934;(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide;(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide;1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)-;2-PYRIMIDINAMINE,4-METHYL-N-[5-METHYL-4-(1H-PYRAZOL-4-YL)-2-THIAZOLYL]-, >98%;Lu AF-21934,Inhibitor,Lu AF 21934,Metabotropic glutamate receptors,inhibit,mGluR,Lu AF21934
- CBNumber:
- CB53129361
- Molecular Formula:
- C14H16Cl2N2O2
- Molecular Weight:
- 315.2
- MDL Number:
- MFCD22576450
- MOL File:
- 1445605-23-1.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
NFPA 704 |
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Lu AF21934 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 27045 | Lu AF21934 | 1445605-23-1 | 5mg | $118 | 2024-03-01 | Buy |
Cayman Chemical | 27045 | Lu AF21934 | 1445605-23-1 | 25mg | $479 | 2024-03-01 | Buy |
Cayman Chemical | 27045 | Lu AF21934 | 1445605-23-1 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 27045 | Lu AF21934 | 1445605-23-1 | 10mg | $214 | 2024-03-01 | Buy |
ApexBio Technology | B6111 | LuAF21934 | 1445605-23-1 | 25mg | $304 | 2021-12-16 | Buy |
Lu AF21934 Chemical Properties,Uses,Production
Biological Activity
ec50: 500 nmlu af21934 is a positive allosteric modulator of mglu4 receptors.the mglu4 receptor subtype of the group iii mglu is mainly a presynaptic auto- or hetero-receptor. its stimulation results in an inhibition of glutamatergic or gabaergic transmission and release
in vitro
lu af21934 has been identified as a brain-penetrating positive allosteric modulator of mglu4 receptors. in broad in-vitro screens, lu af21934 could potentiate the glutamate response at the mglu4 receptor with an emax=120% and a glutamate fold-shift fs=5. lu af21934 did not showed any significant affinity for 70 gpcrs at 10 μm, but acted as a weak positive allosteric modulator of mglu6 receptor, as well as an antagonist of adenosine a2a and 5-ht2b receptors [1].
in vivo
in rats, harmaline triggered tremor as manifested by an increase in the power within 9-15hz band and in the tremor index. harmaline also induced a biphasic effect on mobility, initially inhibiting the exploratory locomotor activity of rats, followed by an increase in their basic activity. lu af21934 at 0.5-5 mg/kg sc did not influence tremor but at doses of 0.5 and 2.5 mg/kg reversed harmaline-induced hyperactivity. mglu4 mrna expression was found to be high in the cerebellar cortex and low in the inferior olive [1].
target
mGlu4 Receptor 500 nM (EC 50 ) |
References
[1] ossowska k,wardas j,berghauzen-maciejewska k,et al. lu af21934, a positive allosteric modulator of mglu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. neuropharmacology.2014 aug;83:28-35.
Lu AF21934 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4182 | 55 | |
ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10004 | 55 |