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TRC051384

TRC051384 Structure
TRC051384 structure
CAS No.
867164-40-7
Chemical Name:
TRC051384
Synonyms
TRC051384;TRC 051384; TRC-051384;TRC051384, 10 mM in DMSO;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-
CBNumber:
CB53171704
Molecular Formula:
C25H31N5O4
Molecular Weight:
465.54
MDL Number:
MFCD28133369
MOL File:
867164-40-7.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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TRC051384 Properties

Boiling point 685.7±55.0 °C(Predicted)
Density 1.260±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO
form solid
pka 13.47±0.46(Predicted)
color Yellow

TRC051384 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 4734 TRC051384 ≥98%(HPLC) 867164-40-7 10 $273 2021-12-16 Buy
Usbiological 256966 TRC 051384 867164-40-7 10mg $545 2021-12-16 Buy
TRC T895540 TRC051384 867164-40-7 10mg $255 2021-12-16 Buy
ChemScene CS-6513 TRC051384 98.19% 867164-40-7 5mg $120 2021-12-16 Buy
ApexBio Technology B7703 TRC051384 867164-40-7 10mg $210 2021-12-16 Buy
Product number Packaging Price Buy
4734 10 $273 Buy
256966 10mg $545 Buy
T895540 10mg $255 Buy
CS-6513 5mg $120 Buy
B7703 10mg $210 Buy

TRC051384 Chemical Properties,Uses,Production

Uses

N-[2-(4-Morpholinyl)ethyl]-N''-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea is a key reactant in the synthesis of TRC051384, which is a small molecule HSP70 inducer.

Biological Activity

trc 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (hsp70) [1]. induction of hsp70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. therefore, induction of hsp70 provides a potential target for the treatment of stroke [1].

in vitro

induction of hsp70 by trc 051384 (6.25, and 12.5 μm) involved heat shock factor-1 (hsf1) activation in hela cells and led to increasing chaperone and anti-inflammatory activity [1]. moreover, trc 051384 (10-50 μm) dose-dependently induced hspa1b overexpression in endothelial cells as well as leucocyte origin [2].

in vivo

trc 051384 (9 mg/kg, intra-peritoneal administration) treatment significantly decreased stroke-associated neuronal injury, disability, and increased survival in a rat model of transient ischemic stroke [1]. in addition, trc 051384 (9 mg/kg, intra-peritoneal administration) delayed thrombus formation without increasing bleeding risk in wt mice [2].

target

hsp70

IC 50

HSP70

References

1. mohanan a, deshpande s, jamadarkhana pg, kumar p, gupta rc, chauthaiwale v, et al. delayed intervention in experimental stroke with trc 051384--a small molecule hsp70 inducer. neuropharmacology. 2011;60(6):991-9. 2. allende m, molina e, guruceaga e, tamayo i, gonzalez-porras jr, gonzalez-lopez tj, et al. hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. cardiovasc res. 2016;110(3):309-18.

TRC051384 Preparation Products And Raw materials

Raw materials

Preparation Products

TRC051384 Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4720 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Lastest Price from TRC051384 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TRC051384 pictures 2024-11-18 TRC051384
867164-40-7
 US $31.00-113.00 / mg 92.66% 10g TargetMol Chemicals Inc.
  • TRC051384 pictures
  • TRC051384
    867164-40-7
  • US $31.00-113.00 / mg
  • 92.66%
  • TargetMol Chemicals Inc.

TRC051384 Spectrum

TRC051384(867164-40-7)1HNMR

867164-40-7(TRC051384)Related Search:

TRC051384 Troparil dichloropane
TRC051384 TRC 051384; TRC-051384 N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]- 1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit TRC051384, 10 mM in DMSO 867164-40-7 API