ChemicalBook >> CAS DataBase List >>GNF-6231
GNF-6231
- CAS No.
- 1243244-74-7
- Chemical Name:
- GNF-6231
- Synonyms
- [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2',3-dimethyl-
- CBNumber:
- CB53333724
- Molecular Formula:
- C25H28N6O2
- Molecular Weight:
- 444.53
- MDL Number:
- MOL File:
- 1243244-74-7.mol
Last updated:2023-03-31 09:12:58
GNF-6231 Chemical Properties,Uses,Production
Description
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.
GNF-6231 Preparation Products And Raw materials
Raw materials
Preparation Products
GNF-6231 Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 023-67770219 | jessica.hu@chemieliva.com | China | 1436 | 60 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |
| Supplier | Advantage |
|---|---|
| InvivoChem | 58 |
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 60 |
| InvivoChem | 58 |
[2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2',3-dimethyl-
1243244-74-7