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AS2553627
- CAS No.
- 1251906-10-1
- Chemical Name:
- AS2553627
- Synonyms
- AS2553627;1-Piperidinepropanenitrile, 3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methyl-β-oxo-, (3R,4R)-
- CBNumber:
- CB53368304
- Molecular Formula:
- C18H19N5O
- Molecular Weight:
- 321.38
- MDL Number:
- MOL File:
- 1251906-10-1.mol
Last updated:2023-03-31 09:12:58
AS2553627 Chemical Properties,Uses,Production
Description
AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.
AS2553627 Preparation Products And Raw materials
Raw materials
Preparation Products
AS2553627 Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
TargetMol Chemicals Inc. | 58 |
AS2553627
1-Piperidinepropanenitrile, 3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methyl-β-oxo-, (3R,4R)-
1251906-10-1