Ascomycin
- CAS No.
- 11011-38-4
- Chemical Name:
- Ascomycin
- Synonyms
- AAG;FK-520;CGTHBA;CS-740;Ascomycin;FR-900520;Nsc106410;Aids093221;IMMUNOMYCIN;Aids-093221
- CBNumber:
- CB5406331
- Molecular Formula:
- C43H69NO12
- Molecular Weight:
- 792.01
- MDL Number:
- MFCD06198665
- MOL File:
- 11011-38-4.mol
Melting point | 158 - 161°C |
---|---|
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming). |
form | White crystalline solid |
color | White |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08,GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H351-H413-H361-H302 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501 |
RTECS | CI7570000 |
Ascomycin price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SAB2501813 | Anti-Nprl3 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 11011-38-4 | 100μG | $568 | 2024-03-01 | Buy |
Sigma-Aldrich | 182800 | Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem An ethyl analog of FK506 with similar immunosuppressant properties. | 11011-38-4 | 1mg | $205 | 2022-05-15 | Buy |
Usbiological | 207066 | Ascomycin | 11011-38-4 | 1mg | $273 | 2021-12-16 | Buy |
Usbiological | A3698-75 | Ascomycin | 11011-38-4 | 25mg | $196 | 2021-12-16 | Buy |
Biorbyt Ltd | orb545956 | Ascomycin >98% | 11011-38-4 | 25mg | $280.5 | 2021-12-16 | Buy |
Ascomycin Chemical Properties,Uses,Production
Description
Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
Uses
A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
General Description
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Biochem/physiol Actions
Product does not compete with ATP.
Enzyme inhibitor
This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
References
1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729
Ascomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12449 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 988 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
View Lastest Price from Ascomycin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-23 | Ascomycin
11011-38-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | ||
2024-03-16 | Ascomycin
11011-38-4
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | ||
2023-11-01 | Ascomycin
11011-38-4
|
US $0.00-0.00 / g | 100g | 99.5% | 100kg | Hangzhou ICH Biofarm Co., Ltd |