2,4,6-Trimethylaniline
- CAS No.
- 88-05-1
- Chemical Name:
- 2,4,6-Trimethylaniline
- Synonyms
- MESIDINE;MESITYLAMINE;2,4,6-trimethylbenzenamine;Mesidin;Mezidine;MESIDENE;AMINOMESITYLENE;Isotritoluidine;2-AMINOMESITYLENE;AKOS BBS-00003561
- CBNumber:
- CB5410640
- Molecular Formula:
- C9H13N
- Molecular Weight:
- 135.21
- MDL Number:
- MFCD00007740
- MOL File:
- 88-05-1.mol
- MSDS File:
- SDS
| Melting point | -5 °C |
|---|---|
| Boiling point | 108-110 °C11 mm Hg(lit.) |
| Density | 0.963 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 205 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | liquid (clear) |
| pka | pK1:4.38(+1) (25°C) |
| color | clear brown |
| Water Solubility | IMMISCIBLE |
| BRN | 636559 |
| InChIKey | KWVPRPSXBZNOHS-UHFFFAOYSA-N |
| CAS DataBase Reference | 88-05-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | YIR5CRL5BG |
| IARC | 3 (Vol. 27, Sup 7) 1987 |
| NIST Chemistry Reference | Benzenamine, 2,4,6-trimethyl-(88-05-1) |
| EPA Substance Registry System | 2,4,6-Trimethylaniline (88-05-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312-H315-H319-H330 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P302+P352+P312-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+,T | |||||||||
| Risk Statements | 21/22-26-36/38-33-23/24/25 | |||||||||
| Safety Statements | 26-28-36/37-45-28A | |||||||||
| RIDADR | UN 2810 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BZ0700000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214980 | |||||||||
| Hazardous Substances Data | 88-05-1(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
2,4,6-Trimethylaniline price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 132179 | 2,4,6-Trimethylaniline 98% | 88-05-1 | 25ml | $47.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 132179 | 2,4,6-Trimethylaniline 98% | 88-05-1 | 100ml | $52.8 | 2024-03-01 | Buy |
| TCI Chemical | T0467 | 2,4,6-Trimethylaniline >99.0%(GC) | 88-05-1 | 25mL | $24 | 2024-03-01 | Buy |
| TCI Chemical | T0467 | 2,4,6-Trimethylaniline >99.0%(GC) | 88-05-1 | 100mL | $47 | 2024-03-01 | Buy |
| Alfa Aesar | A13049 | 2,4,6-Trimethylaniline, 98% | 88-05-1 | 100g | $52.2 | 2024-03-01 | Buy |
2,4,6-Trimethylaniline Chemical Properties,Uses,Production
Chemical Properties
clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.
Uses
2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.
Preparation
2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.
Definition
ChEBI: 2,4,6-Trimethylaniline is a substituted aniline.
General Description
2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.
Reactivity Profile
2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.
Fire Hazard
When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.
Safety Profile
Poison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Potential Exposure
Used on small scale in organic synthesis.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
2,4,6-Trimethylaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9691 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29857 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2957 | 58 |
View Lastest Price from 2,4,6-Trimethylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-15 | 2,4,6-Trimethylaniline
88-05-1
|
US $120.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-03-21 | 2,4,6-Trimethylaniline
88-05-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2024-10-11 | 2,4,6-Trimethylaniline
88-05-1
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,4,6-Trimethylaniline
88-05-1
- US $120.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 2,4,6-Trimethylaniline
88-05-1
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2,4,6-Trimethylaniline
88-05-1
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD