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Boc-Hyp-OH

Boc-Hyp-OH structure

CAS No.: 13726-69-7

Chemical Name:: Boc-Hyp-OH

Synonyms: (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;BOC-HYP-OH;BOC-HYP;BOC-L-HYP-OH;N-BOC-L-HYDROXYPROLINE;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;(2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylic Acid;N-ter;Teneint-E;oc-L-Hyp-OH

CBNumber:: CB5411793

Molecular Formula:: C10H17NO5

Molecular Weight:: 231.25

MDL Number:: MFCD00053370

MOL File:: 13726-69-7.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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Boc-Hyp-OH Properties

Melting point	123-127 °C(lit.)
alpha	-78 º (in H2O)
Boiling point	390.9±42.0 °C(Predicted)
Density	1.312±0.06 g/cm3(Predicted)
refractive index	-68 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.80±0.40(Predicted)
color	White to off-white
optical activity	[α]20/D 53.5±2°, c = 1% in DMF
Water Solubility	very faint turbidity
BRN	4295484
InChIKey	BENKAPCDIOILGV-RQJHMYQMSA-N
CAS DataBase Reference	13726-69-7(CAS DataBase Reference)
FDA UNII	RC99P5B8IG
EPA Substance Registry System	(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

22-24/25

WGK Germany

HS Code

2933 99 80

HazardClass

IRRITANT

NFPA 704

	1
1		0

Boc-Hyp-OH price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53026	Boc-Hyp-OH (cryst) Novabiochem?	13726-69-7	25g	$344	2024-03-01	Buy
Sigma-Aldrich	8.53026	Boc-Hyp-OH (cryst) Novabiochem?	13726-69-7	100g	$1030	2024-03-01	Buy
Sigma-Aldrich	15544	Boc-Hyp-OH ≥98.0% (TLC)	13726-69-7	5g	$36.6	2024-03-01	Buy
Sigma-Aldrich	15544	Boc-Hyp-OH ≥98.0% (TLC)	13726-69-7	25g	$150	2024-03-01	Buy
TCI Chemical	B1635	trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline >98.0%(T)	13726-69-7	5g	$18	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.53026	25g	$344	Buy
8.53026	100g	$1030	Buy
15544	5g	$36.6	Buy
15544	25g	$150	Buy
B1635	5g	$18	Buy

Boc-Hyp-OH Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Biological Activity

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-Hyp-OH Preparation Products And Raw materials

Raw materials

Preparation Products

N-Boc-4-oxo-L-Proline methyl ester 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-cis-4-fluoro-L-proline H-Hyp(Bzl)-OH · HCl

tert-butyl (S)-7-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

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Boc-Hyp-OH Suppliers

Global( 498)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	+86-86020003 +86-18861157602	sales03@genchem.cn	China	104	58
Nanjing Sinoda Biological Technology Co., Ltd	+8613401983379	sales@njmcn.cn	CHINA	74	58
PRISUN PHARMATECH CO.,LTD	+86-021-54326183-8001 +8618917565227	prisun@prisunpharma.com	China	215	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1262	58
Wuhan Fortuna Chemical Co.,Ltd	+8618007136271	hk@fortunachem.com	China	6000	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19852	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21631	55

Supplier	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Nanjing Sinoda Biological Technology Co., Ltd	58
PRISUN PHARMATECH CO.,LTD	58
BTC pharm India	58
Wuhan Fortuna Chemical Co.,Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Boc-Hyp-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-03-14	boc-L-hydroxyproline 13726-69-7	US $0.00-0.00 / kg	1kg	99%	1000kg	Wuhan Fortuna Chemical Co.,Ltd
2025-03-13	Boc-L-Hydroxyproline 13726-69-7	US $0.00-0.00 / Kg/Drum	1KG	99%HPLC	10 Tons	WUHAN FORTUNA CHEMICAL CO., LTD
2025-03-13	Boc-Hyp-OH 13726-69-7	US $0.00 / Kg/Drum	1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD

boc-L-hydroxyproline
13726-69-7
US $0.00-0.00 / kg
99%
Wuhan Fortuna Chemical Co.,Ltd

Boc-L-Hydroxyproline
13726-69-7
US $0.00-0.00 / Kg/Drum
99%HPLC
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Hyp-OH
13726-69-7
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Hyp-OH Spectrum

Boc-L-Hydroxyproline(13726-69-7)MS Boc-L-Hydroxyproline(13726-69-7)¹³CNMR Boc-L-Hydroxyproline(13726-69-7)IR1 Boc-L-Hydroxyproline(13726-69-7)IR2

13726-69-7(Boc-Hyp-OH)Related Search:

L-Hydroxyproline BOC-D-PHE-OSU Boc-D-Valine 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Methyl N-(tert-butoxycarbonyl)-L-threoninate

Boc-L-serine methyl ester BOC-GUANIDINE BOC-L-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,BOC-HYP-OME / BOC-L-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH 1-Boc-L-hydroxyproline ethyl ester

N-Boc-trans-4-tosyloxy-L-proline methyl ester (2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER Boc-Hyp-OH BOC-CIS-HYDROXYPROLINE-OME L-Proline

(2S,4R)-BOC-4-(2-NAPHTHYLMETHOXY)-PYRROLIDINE-2-CARBOXYLIC ACID BOC-HYP-OH DCHA (2S,4R)-BOC-4-(2-NAPHTHYLOXY)-PYRROLIDINE-2-CARBOXYLIC ACID

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(2S,4R)-N-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid Boc-(2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic Acid N-ter N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline ,98% Boc-L-trans-hydroxyproline(Boc-trans-Hyp-OH) ,98.5%(HPLC) 1,2-Pyrrolidinedicarboxylicacid,4-hydroxy-,1-(1,1-diMethylethyl)ester,(2S,4R)- (2S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid trans-N-Boc-4-hydroxy-L-proline trans-Boc-Hyp-OH (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester (2S,4R)-1-(tertbutoxycarbonyl-4-hydroxypyrrolidine acid Boc-Hyp-OH, >=98.0% trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline N-Boc-(2S,4R)-4-hydroxyproline BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID BOC-L-HYDROXYPROLINE BOC-L-4-HYDROXYPROLINE BOC-HYDROXYPROLINE BOC-TRANS-HYP-OH BOC-TRANS-4-HYDROXY-L-PROLINE BOC-L-T-4-HYDROXYPROLINE BOC-L-TRANS-4-HYDROXYPROLINE Boc-L-trans-4-hydroxyproline≥ 99% (Assay) Boc-Hyp-OH (cryst) Novabiochem Boc-Hyp-OH >=98.0% (TLC) (2S,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID RARECHEM EM WB 0136 N-T-BOC-TRANS-4-HYDROXY-L-PROLINE N-(TERT-BUTOXYCARBONYL)-L-4-HYDROXYPROLINE N-TERT-BUTOXYCARBONYL-L-HYDROXYPROLINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE N-ALPHA-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINE （2S，4R)-1-（tertbutoxycarbonyl）-4-hydroxypyrrolidine carboxylic acid BOC-HYPOZANTHINE extrapure Boc-L-hydroxyproline, trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline trans-Boc-Hyp-OH trans-N-Boc-4-hydroxy-L-proline 1-[(tert-Butoxy)carbonyl]-4-hydroxy-L-proline N-ALPHA-T-BOC-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-T-BUTOXYCARBONYL-L-HYDROXYPROLINE N-ALPHA-T-BOC-L-HYDROXYPROLINE N-ALPHA-T-BOC-L-TRANS-4-HYDROXYPROLINE N-BOC-TRANS-4-HYDROXY-L-PROLINE N-BOC-L-4-HYDROXYPROLINE N-BOC-L-TRANS-4-HYDROXYPROLINE N-BOC-4-HYDROXY-L-PROLINE TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY-L-PROLINE Butoxycarbonylhydroxypyroline Boc-4-hydroxy-L-proline TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY- N-(TERT-BUTOXYCARBONYL)-L-4-HYDROXYPROLINEBOC-L-HYP-OH TERT-BUTYLOXYCARBONYLHYDROXYPROLINE 4-hydroxy-1-tert-butoxycarbonyl-pyrrolidine-2-carboxylic acid N-ALPHA-T-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE BOC TRANS 4 HYDROXY L PROLINE, METHYL ESTER (BOC H NALPHA-tert-Butoxycarbonyl-trans-4-hydroxy-L-proline N-tert-Butoxycarbonyl-Trans-4-hydroxy-L-proline (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Animal Origin) (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Non-Animal Origin)