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Megestrol

CAS No.
3562-63-8
Chemical Name:
Megestrol
Synonyms
C07120;Megestro;MEGESTROL;Megestrol USP/EP/BP;Megestrol in Methanol;megestrol solution,100ppm;Megestrol acetate EP Impurity B;Megestrol 100 μg/ml Acetonitrile;Metesterone acetate EP impurity B;4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
CBNumber:
CB5465978
Molecular Formula:
C22H30O3
Molecular Weight:
342.47
MDL Number:
MFCD01939877
MOL File:
3562-63-8.mol
MSDS File:
SDS
Last updated:2024-10-28 16:48:35

Megestrol Properties

Melting point 207-208 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1))
Boiling point 500.4±50.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 13.00±0.70(Predicted)
color White to Off-White
CAS DataBase Reference 3562-63-8(CAS DataBase Reference)
FDA UNII EA6LD1M70M
ATC code G03AC05,G03DB02,L02AB01

Megestrol price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M208040 Megestrol 3562-63-8 50mg $145 2021-12-16 Buy
Usbiological M2860-55B Megestrol 3562-63-8 500ul $306 2021-12-16 Buy
TRC M208040 Megestrol 3562-63-8 500mg $1165 2021-12-16 Buy
American Custom Chemicals Corporation API0006501 MEGESTROL 95.00% 3562-63-8 500MG $1686.3 2021-12-16 Buy
ChemScene CS-0013903 Megestrol 99.69% 3562-63-8 100mg $200 2021-12-16 Buy
Product number Packaging Price Buy
M208040 50mg $145 Buy
M2860-55B 500ul $306 Buy
M208040 500mg $1165 Buy
API0006501 500MG $1686.3 Buy
CS-0013903 100mg $200 Buy

Megestrol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.

Indications

As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.

Definition

ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.

brand name

Megace (Bristol-Myers Squibb); Megace (Par);Citestrol;Co-ervonum;Combiquens;Femagest;Kombiquens;Megecat;Megeron;Megestat;Menoquens;Neo-delpregnin;Niaestine;Niagestine;Novaquin;Novokvens;Novolina;Novoquens;Oracolnal;Ovaban;Ovarid;Pallace;Serial 28;Volidan;Volplan.

World Health Organization (WHO)

Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Synthesis

Megestrol, 17|á-hydroxy-6|á-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6¨CC7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid.

Synthesis_3562-63-8

Megestrol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 161)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387 1057@dideu.com China 3958 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325 sales1@chuanghaibio.com China 5893 58
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Hebei shuoxi biotechnology co. LTD
+8613081092107 CHINA 964 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12841 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32079 58
Hebei Lihe Biotechnology Co.,ltd
86-311-80292533 13315122300 sales@lihebiotech.com CHINA 298 58

View Lastest Price from Megestrol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Megestrol pictures 2024-10-28 Megestrol
3562-63-8
US $30.00 / mg 10g TargetMol Chemicals Inc.
Megestrol pictures 2024-10-11 Megestrol
3562-63-8
US $10.50 / KG 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
Megestrol pictures 2024-07-20 Megestrol
3562-63-8
US $1.00 / Kg 1Kg 98% 20T Shaanxi Dideu Medichem Co. Ltd
  • Megestrol pictures
  • Megestrol
    3562-63-8
  • US $30.00 / mg
  • TargetMol Chemicals Inc.
  • Megestrol pictures
  • Megestrol
    3562-63-8
  • US $10.50 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • Megestrol pictures
  • Megestrol
    3562-63-8
  • US $1.00 / Kg
  • 98%
  • Shaanxi Dideu Medichem Co. Ltd
17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE 17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE MEGESTROL 17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione Megestrol (base and/or unspecified salts) C07120 megestrol solution,100ppm (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one Megestrol acetate EP Impurity B Megestrol Acetate Impurity 2(Megestrol Acetate EP Impurity B)(Megestrol) Megestro Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- Megestrol Acetate Impurity 2(Megestrol Acetate EP Impurity B) Metesterone acetate EP impurity B Megestrol USP/EP/BP Megestrol in Methanol Megestrol 100 μg/ml Acetonitrile 3562-63-8 Hormone Drugs Intermediates & Fine Chemicals Pharmaceuticals Steroids 3562-63-8