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M-443

M-443 structure

CAS No.: 1820684-31-8

Chemical Name:: M-443

Synonyms: M-443;M-443 (M443;Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-

CBNumber:: CB54668159

Molecular Formula:: C31H30F3N7O2

Molecular Weight:: 589.61

MDL Number:: MFCD31692382

MOL File:: 1820684-31-8.mol

Last updated:2024-07-02 08:55:11

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M-443 Properties

Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 55 mg/mL (93.28 mM)
form	Solid
pka	12.95±0.70(Predicted)
color	Light yellow to yellow

M-443 Chemical Properties,Uses,Production

Description

M443 is a specific small molecule inhibitor of MRK. M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest.

M-443 Preparation Products And Raw materials

Raw materials

Preparation Products

M-443 Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai hongqu biomedical technology co. LTD	88888888888	hongquchem@qq.com	China	5132	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10011	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai hongqu biomedical technology co. LTD	58
cjbscvictory	58
TargetMol Chemicals Inc.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

M-443 M-443 (M443 Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]- 1820684-31-8 C31H30F3N7O2