[2H3]-Quinidine
- CAS No.
- 1267657-68-0
- Chemical Name:
- [2H3]-Quinidine
- Synonyms
- [2H3]-Quinidine;(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl][6-(2H?)methoxyquinolin-4-yl]methanol
- CBNumber:
- CB54800739
- Molecular Formula:
- C20H24N2O2
- Molecular Weight:
- 324.42
- MDL Number:
- MFCD09841218
- MOL File:
- 1267657-68-0.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H315 | |||||||||
Precautionary statements | P264-P270-P301+P310-P321-P330-P302+P352-P362+P364-P332+P313-P405-P501 | |||||||||
NFPA 704 |
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[2H3]-Quinidine price More Price(3)
[2H3]-Quinidine Chemical Properties,Uses,Production
Description
Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.1,2 Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.1 It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.3 Quinidine inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 μM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 μM.2 It induces QT prolongation in dogs.4 Quinidine also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 μM for human recombinant receptors expressed in HM2-B10 cells).5 Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Uses
A dextrorotatory stereoizomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
References
1. Roden, D.M. Pharmacology and toxicology of Nav1.5-
2. Wu, L., Guo, D., Li, H., et al. Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine Heart Rhythm 5(12),1726-1734(2008).
3. Salata, J.J., and Wasserstrom, J.A. Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes Circ. Res. 62(2),324-337(1988).
4. Rakhit, A., Guentert, T.W., Holford, N.H.G., et al. Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-
5. Kovacs, I., Yamamura, H.I., Waite, S.L., et al. Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line J. Pharmacol. Exp. Ther. 284(2),500-507(1998).
[2H3]-Quinidine Preparation Products And Raw materials
Raw materials
Preparation Products
[2H3]-Quinidine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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