ChemicalBook >> CAS DataBase List >>GGTI-286 dihydrochloride
(GGTI286)
GGTI-286 dihydrochloride (GGTI286)
- CAS No.
- 181141-66-2
- Chemical Name:
- GGTI-286 dihydrochloride (GGTI286)
- Synonyms
- GGTI-286 hydrochloride;GGTI-286 dihydrochloride (GGTI286)
- CBNumber:
- CB54844799
- Molecular Formula:
- C23H32ClN3O3S
- Molecular Weight:
- 466.04
- MDL Number:
- MOL File:
- 181141-66-2.mol
Last updated:2024-10-23 13:36:13
GGTI-286 dihydrochloride (GGTI286) Chemical Properties,Uses,Production
Biological Activity
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2].
References
[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.
GGTI-286 dihydrochloride (GGTI286) Preparation Products And Raw materials
Raw materials
Preparation Products
GGTI-286 dihydrochloride (GGTI286) Suppliers
Global( 3)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19863 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3983 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from GGTI-286 dihydrochloride (GGTI286) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | GGTI-286 hydrochloride
181141-66-2
|
US $2785.00-2140.00 / mg | 10g | TargetMol Chemicals Inc. |
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- GGTI-286 hydrochloride
181141-66-2
- US $2785.00-2140.00 / mg
- TargetMol Chemicals Inc.
GGTI-286 dihydrochloride
(GGTI286)
GGTI-286 hydrochloride
181141-66-2