Indoline
- CAS No.
- 496-15-1
- Chemical Name:
- Indoline
- Synonyms
- Dihydroindole;2,3-DIHYDRO-1H-INDOLE;2,3-DIHYDROINDOLE;1H-Indole, 2,3-dihydro-;IDN;NDOLINE;INDOLINE;1-Azaindan;1H-Indoline;Indoline>
- CBNumber:
- CB5485525
- Molecular Formula:
- C8H9N
- Molecular Weight:
- 119.16
- MDL Number:
- MFCD00005705
- MOL File:
- 496-15-1.mol
- MSDS File:
- SDS
| Melting point | -21 °C |
|---|---|
| Boiling point | 220-221 °C (lit.) |
| Density | 1.063 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 199 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 5g/l; lnsoluble in water, soluble in alcohol and oils. Poorly soluble in Propylene glycol. |
| form | liquid (clear) |
| pka | 5.20±0.20(Predicted) |
| color | clear dark brown |
| Odor | a mild, delicate, but extremely tenacious floral odor |
| Water Solubility | 5 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| BRN | 111915 |
| CAS DataBase Reference | 496-15-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6DPT9AB2NK |
| NIST Chemistry Reference | 1H-Indole, 2,3-dihydro-(496-15-1) |
| EPA Substance Registry System | 1H-Indole, 2,3-dihydro- (496-15-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210e-P261-P280a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL6906300 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339990 | |||||||||
| NFPA 704 |
|
Indoline price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I5605 | Indoline ReagentPlus , 99% | 496-15-1 | 25g | $40.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | I5605 | Indoline ReagentPlus , 99% | 496-15-1 | 100g | $71.4 | 2024-03-01 | Buy |
| TCI Chemical | I0033 | Indoline >98.0%(GC)(T) | 496-15-1 | 25mL | $34 | 2024-03-01 | Buy |
| TCI Chemical | I0033 | Indoline >98.0%(GC)(T) | 496-15-1 | 250mL | $191 | 2024-03-01 | Buy |
| Alfa Aesar | A11000 | Indoline, 99% | 496-15-1 | 50g | $61.7 | 2024-03-01 | Buy |
Indoline Chemical Properties,Uses,Production
Chemical Properties
?2,3-Dihydroindole [496-15-1], indoline C8H9N, Mr 119.16, bp 229 – 230 ℃(101.3 kPa), is a colorless liquid, which is volatile in steam and soluble in diethyl ether, acetone, and benzene, but only slightly soluble in water. Indoline is obtained by hydrogenation of indole or by catalytic cyclodehydration of 2-(2-aminophenyl)ethanol. A range of pharmaceuticals, as well as fungicides and bactericides, can be produced from indoline.
Uses
As an indole derivative, Indoline can be used in the preparation of various medicinal compounds such as potential α1-adrenoceptor (α1-AR) antagonists.
Uses
Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines.
Uses
Reactant for preparation of:
- Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
- Sphingosine-1-phosphate 4(S1P4) receptor antagonists
- Cytotoxic cell cycle inhibitors
- 2-Aminopyridines
- PET agent for imaging of protein kinase C (PKC)
- Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
- α4β2-Nicotinic acetylcholine receptor-selective partial agonists
- mGlu4 positive allosteric modulators
- Bacterial biofilm inhibitors
- Serotonin 5-HT6 receptor antagonists
Definition
ChEBI: Indoline is a member of indoles.
Synthesis Reference(s)
Journal of the American Chemical Society, 96, p. 7812, 1974 DOI: 10.1021/ja00832a035
Synthetic Communications, 13, p. 489, 1983 DOI: 10.1080/00397918308081827
Synthesis
Indolene is manufactured from (theoretically) 2 Mol. Indole plus 1 Mol. Hydroxycitronellal by condensation under heating. The proportions may vary slightly, and it is common practice to add Diethyl phthalate to the mixture prior to heating, so that the condensation product is somewhat protected against local overheating, and the finished product becomes light of color and fairly pourable at room temperature.
Indoline Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 | lucy@verychem.com | China | 1054 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
View Lastest Price from Indoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Indoline
496-15-1
|
US $10.00 / KG | 1KG | 99% | 100 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-11-28 | Indoline
496-15-1
|
US $5.00 / kg | 1kg | ≥99% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-11-27 | Indoline
496-15-1
|
US $1.00 / KG | 1KG | 99.0%-100.00% | 200kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |