3,5-Diiodo-L-tyrosine dihydrate
- CAS No.
- 300-39-0
- Chemical Name:
- 3,5-Diiodo-L-tyrosine dihydrate
- Synonyms
- (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
- CBNumber:
- CB5490149
- Molecular Formula:
- C9H9I2NO3
- Molecular Weight:
- 432.98
- MDL Number:
- MFCD00016542
- MOL File:
- 300-39-0.mol
Melting point | 200 °C (dec.)(lit.) |
---|---|
alpha | -20.7 º (c=2.5, 0.1N NaOH/H2O) |
Boiling point | 546.5°C (rough estimate) |
Density | 2.405±0.06 g/cm3(Predicted) |
refractive index | 1.2 ° (C=5, 1mol/L HCl) |
storage temp. | 2-8°C |
solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
form | crystalline |
pka | 2.12(at 25℃) |
color | white |
Water Solubility | slightly soluble |
Sensitive | Light Sensitive |
CAS DataBase Reference | 300-39-0(CAS DataBase Reference) |
FDA UNII | 6L57Q44ZWW |
ATC code | H03BX01 |
NIST Chemistry Reference | 3,5-Diiodo-l-tyrosine(300-39-0) |
EPA Substance Registry System | L-Tyrosine, 3,5-diiodo- (300-39-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-37/39-36/37-24/25 | |||||||||
RIDADR | 2811 | |||||||||
WGK Germany | 3 | |||||||||
F | 8 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29225090 | |||||||||
NFPA 704 |
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3,5-Diiodo-L-tyrosine dihydrate price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | H65420 | 3,5-Diiodo-L-tyrosine, 95% | 300-39-0 | 25g | $66.5 | 2021-12-16 | Buy |
Alfa Aesar | H65420 | 3,5-Diiodo-L-tyrosine, 95% | 300-39-0 | 100g | $210 | 2021-12-16 | Buy |
TRC | D466055 | 3,5-Diiodo-L-tyrosine | 300-39-0 | 5g | $85 | 2021-12-16 | Buy |
TRC | D466055 | 3,5-Diiodo-L-tyrosine | 300-39-0 | 25g | $185 | 2021-12-16 | Buy |
Biosynth Carbosynth | FD46930 | 3,5-Diiodo-L-tyrosine | 300-39-0 | 500g | $175 | 2021-12-16 | Buy |
3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Uses,Production
Description
Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.
Chemical Properties
white to beige powder
Uses
3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.
Uses
It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.
Uses
3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.
Definition
ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.
Synthesis
Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.
Purification Methods
It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]
3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | sales@ryanchem.com | China | 137 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12495 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1080 | 58 |
View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
|
US $0.00 / Kg/Bag | 100g | 98%min | 100kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-15 | 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
|
US $20.00-1.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | ||
2023-10-11 | 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
- US $20.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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