ChemicalBook >> CAS DataBase List >>EBI-907
EBI-907
- CAS No.
- 1581764-31-9
- Chemical Name:
- EBI-907
- Synonyms
- EBI-907;1-Propanesulfonamide, N-[2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl]-3-fluoro-
- CBNumber:
- CB54919860
- Molecular Formula:
- C23H21ClF2N4O3S
- Molecular Weight:
- 506.95
- MDL Number:
- MFCD32204697
- MOL File:
- 1581764-31-9.mol
Last updated:2023-03-31 09:12:57
EBI-907 Chemical Properties,Uses,Production
Description
EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases including BRK, FGFR1, c-Kit, and PDGFRb.
EBI-907 Preparation Products And Raw materials
Raw materials
Preparation Products
EBI-907 Suppliers
Global( 3)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12005 | 58 |
| Supplier | Advantage |
|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
EBI-907
1-Propanesulfonamide, N-[2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl]-3-fluoro-
1581764-31-9