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JC-1

CAS No.
3520-43-2
Chemical Name:
JC-1
Synonyms
JC-1;VIS515;JC-1, >95%;JC-1 jodide;CBIC2, >95%;ChemicalbookCBIC2,>95%;JC-1[5,5,6,6-Tetrachloro-1,1,3,3;-tetrachloroimidacarbocyanine iodide;inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor;5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA
CBNumber:
CB5497188
Molecular Formula:
C25H27Cl4N4.I
Molecular Weight:
652.228
MDL Number:
MFCD00188475
MOL File:
3520-43-2.mol
Last updated:2024-11-13 11:39:26

JC-1 Properties

Melting point 275–278 ℃
storage temp. room temp
solubility Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide
form crystals
color Deep red
λmax 514nm
Stability Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO or distilled water may be stored at 4°C for up to 1 year. DO NOT FREEZE/THAW SOLUTIONS. Sterilize solutions only by filtration, not by autoclaving
Biological Applications Detectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity
Major Application Langmuir-Blodgett films; lasing systems; nonlinear optical materials; photographic materials1,
InChIKey FYNNIUVBDKICAX-UHFFFAOYSA-M

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H410-H335-H319-H302
Precautionary statements  P273-P391-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
WGK Germany  3
10-21
NFPA 704
0
2 0

JC-1 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T4069 JC-1 solid 3520-43-2 5mg $632 2024-03-01 Buy
Cayman Chemical 15003 JC-1 ≥90% 3520-43-2 1mg $68 2024-03-01 Buy
Cayman Chemical 15003 JC-1 ≥90% 3520-43-2 5mg $302 2024-03-01 Buy
Cayman Chemical 15003 JC-1 ≥90% 3520-43-2 10mg $535 2024-03-01 Buy
TRC J211955 JC-1iodide 3520-43-2 2.5mg $275 2021-12-16 Buy
Product number Packaging Price Buy
T4069 5mg $632 Buy
15003 1mg $68 Buy
15003 5mg $302 Buy
15003 10mg $535 Buy
J211955 2.5mg $275 Buy

JC-1 Chemical Properties,Uses,Production

Description

JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis. It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry. A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers). JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.

Uses

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc

Uses

The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.

Definition

ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.

References

1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480 2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671 3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1 4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905 5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 97)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Jiangxi Lotchem Co.,Ltd.
+8615270827708 lancetu@jxlotchem.com CHINA 338 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203 info@chemextension.com China 42056 58

View Lastest Price from JC-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JC-1 pictures 2024-11-12 JC-1
3520-43-2
US $59.00-153.00 / mg 99.58% 10g TargetMol Chemicals Inc.
JC-1 pictures 2020-01-05 JC-1
3520-43-2
US $1.00 / KG 1KG 95--99% 1ton Career Henan Chemical Co
  • JC-1 pictures
  • JC-1
    3520-43-2
  • US $59.00-153.00 / mg
  • 99.58%
  • TargetMol Chemicals Inc.
  • JC-1 pictures
  • JC-1
    3520-43-2
  • US $1.00 / KG
  • 95--99%
  • Career Henan Chemical Co

JC-1 Spectrum

5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide JC-1 JC-1,5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3) JC-1 jodide 1h-benzimidazolium, 5,6-dichloro-2[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2h-benzimidazol-2-ylidene)-1-propenyl]-1,3-diethyl-, Iodide 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethylbenzimidazolium Iodide Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethyl-, Iodide Benzimidazolocarbocyanine Iodide, 5,50,6,60-tetrachloro-1,10,3,30-tetraethyl- Imidacarbocyanine Iodide, 1,10,3,30-tetraethyl-5,50,6,60-tetrachloro- 1,10,3,30-tetraethyl-5,50,6,60-tetrachlorobenzimidazolocarbocyanine Iodide 1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide 5,50,6,60-tetrachloro-1,10,3,30-tetraethylbenzimidazolocarbocyanine Iodide 5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide (47729-63-5) 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide CBIC2, >95% JC-1, >95% JC-1 [5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] *CAS#: 3520-43-2* 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole -tetrachloroimidacarbocyanine iodide ChemicalbookCBIC2,>95% JC-1[5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] JC-1[5,5,6,6-Tetrachloro-1,1,3,3 inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor VIS515 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide JC-1 mitochondrial membrane potential fluorescent probe 3520-43-2 Cyanine