ChemicalBook >> CAS DataBase List >>Dermorphin

Dermorphin

CAS No.
77614-16-5
Chemical Name:
Dermorphin
Synonyms
DERMORPHIN;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;dermorphin/DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
CBNumber:
CB5498044
Molecular Formula:
C40H50N8O10
Molecular Weight:
802.87
MDL Number:
MFCD00076694
MOL File:
77614-16-5.mol
MSDS File:
SDS
Last updated:2024-12-10 11:57:34

Dermorphin Properties

Melting point 157-159 °C
Boiling point 1323.8±65.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO
form powder
pka 9.83±0.15(Predicted)
color white to off-white
Sequence H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChIKey FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1
FDA UNII 2SEC01B703

SAFETY

Risk and Safety Statements

WGK Germany  3

Dermorphin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J62019 Dermorphin 77614-16-5 5mg $194 2021-12-16 Buy
ChemScene CS-7103 Dermorphin 99.64% 77614-16-5 10mg $216 2021-12-16 Buy
Biosynth Carbosynth FD108711 Dermorphin 77614-16-5 250mg $250 2021-12-16 Buy
Biosynth Carbosynth FD108711 Dermorphin 77614-16-5 500mg $375 2021-12-16 Buy
American Custom Chemicals Corporation PEP0001209 DERMORPHIN 95.00% 77614-16-5 1MG $427.2 2021-12-16 Buy
Product number Packaging Price Buy
J62019 5mg $194 Buy
CS-7103 10mg $216 Buy
FD108711 250mg $250 Buy
FD108711 500mg $375 Buy
PEP0001209 1MG $427.2 Buy

Dermorphin Chemical Properties,Uses,Production

Description

Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa.  It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.

Uses

A mu-opioid receptor agonist

Definition

ChEBI: Dermorphin is an oligopeptide.

Side effects

Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].

in vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.

References

[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

Dermorphin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 117)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109 xinshengkeji@xsmaterial.com China 1085 58
Hebei Weimiao Import and Export Trade Co., Ltd.
+86-19948166995 +86-19948166995 sale01@hbweimiao.com China 76 58
Hebei Xunou new energy Technology Co., LTD
+86-17531957005; +undefined17531957005 xunou8@hbxunou.com China 36 58
Strong peptide cross-border e-commerce Co. LTD
+undefined13930052870 qt01@qiangtaipharm.com China 84 58
Hebei Yime New Material Technology Co., Ltd.
+86-66697723 +86-17703311139 admin@china-yime.com China 563 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Anhui Zhongda Biotechnology Co., Ltd
+8619956560829 justine@zhongda-biotech.com China 286 58
Anhui Ruihan Technology Co., Ltd
+8617756083858 daisy@anhuiruihan.com China 973 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 615 58
Shandong Hanjiang Chemical Co., Ltd
+86-0533-2066820 +8618369939125 hanson@sdhanjiang.com China 1000 58

View Lastest Price from Dermorphin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DERMORPHIN ACETATE pictures 2024-12-14 DERMORPHIN ACETATE
77614-16-5
US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
Dermorphin pictures 2024-12-13 Dermorphin
77614-16-5
US $200.00-95.00 / kg 1kg 99% 500000 Pieces Per Year Hebei Zhuanglai Chemical Trading Co.,Ltd
Dermorphin pictures 2024-12-13 Dermorphin
77614-16-5
US $80.00-75.00 / box 1box 99+ 2000box Strong peptide cross-border e-commerce Co. LTD
  • Dermorphin pictures
  • Dermorphin
    77614-16-5
  • US $200.00-95.00 / kg
  • 99%
  • Hebei Zhuanglai Chemical Trading Co.,Ltd
  • Dermorphin pictures
  • Dermorphin
    77614-16-5
  • US $80.00-75.00 / box
  • 99+
  • Strong peptide cross-border e-commerce Co. LTD
DERMORPHIN ACETATE L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2 Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide Dermorphin trifluoroacetate salt Dermorphin Powder (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide Dermorphin HAc (2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro DERMORPHIN dermorphin/DERMORPHIN ACETATE 77614-16-5 77614-16-5