HOLOCALIN(P)

CAS No.
101-93-9
Chemical Name:
HOLOCALIN(P)
Synonyms
Holocaine;Halocaine;Tanicaine;Fenacaine;Phenacaine;HOLOCALIN(P);N,N-bis(4-ethoxyphenyl)acetamidine;n,n’-bis(p-ethoxyphenyl)acetamidine;n,n’-bis(p-ethoxyphenyl)-acetamidin;N,N'-Bis(p-ethoxyphenyl)acetamidine
CBNumber:
CB5506961
Molecular Formula:
C18H22N2O2
Molecular Weight:
298.38
MDL Number:
MFCD00242598
MOL File:
101-93-9.mol
Last updated:2023-05-04 17:34:30

HOLOCALIN(P) Properties

Melting point 117°C
Boiling point 439.8°C (rough estimate)
Density 1.1301 (rough estimate)
refractive index 1.5350 (estimate)
pka 9.95±0.50(Predicted)
FDA UNII V3M4D317W8

HOLOCALIN(P) Chemical Properties,Uses,Production

Originator

Phenacaine, ZYF Pharm Chemical

Definition

ChEBI: Phenacaine is an aromatic ether.

Manufacturing Process

Phenacetin (4-ethoxyacetanilide) was treated with slowly current of gaseous hydrogen chloride for 15 hours at 150°C. On cooling the product was poured into 20 volumes of water and heated. Then it was cooled to room temperature, filtered off and excess of alkali was added. The precipitated crude product was at first re-crystallized from 60% ethanol, then from benzene-ligroin to give pure acetamidine as a white needles; MP: 121°C.

brand name

Holocaine Hydrochloride (Abbott).

Therapeutic Function

Local anesthetic

156-43-4
75-05-8
101-93-9
Synthesis of HOLOCALIN(P) from Phenetidine and Acetonitrile

HOLOCALIN(P) Preparation Products And Raw materials

Raw materials

Preparation Products

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Halocaine Holocaine n,n’-bis(4-ethoxyphenyl)-ethanimidamid n,n’-bis(4-ethoxyphenyl)ethanimidamidemonohydrochloride n,n’-bis(p-ethoxyphenyl)-acetamidin n,n’-bis(p-ethoxyphenyl)acetamidine N',N2-Bis(p-ethoxyphenyl)acetamidine N,N'-Bis(p-ethoxyphenyl)acetamidine n’,n(sup2)-bis(p-ethoxyphenyl)acetamidine Phenacaine Tanicaine N,N-bis(4-ethoxyphenyl)acetamidine N1,N2-Bis(4-ethoxyphenyl)acetamidine N,N'-bis(4-ethoxyphenyl)ethanimidamide HOLOCALIN(P) (1Z)-N,N'-Bis(4-ethoxyphenyl)ethanimidamide Ethanimidamide, N,N'-bis(4-ethoxyphenyl)- Fenacaine 101-93-9 Alkaloids