CC-90011
- CAS No.
- 2097523-60-7
- Chemical Name:
- CC-90011
- Synonyms
- CC-90011;CC-90011 besylate;CC-90011 besylicacid;LSD1-IN-7 benzenesulfote;CC-90011 benzenesulfonate;LSD1-IN-7 benzenesulfonate;Pulrodemstat benzenesulfonate;Pulrodemstat (CC90011) besylate;Pulrodemstat benzenesulfonate, 10 mM in DMSO;CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
- CBNumber:
- CB55544449
- Molecular Formula:
- C30H29F2N5O5S
- Molecular Weight:
- 609.65
- MDL Number:
- MFCD32644589
- MOL File:
- 2097523-60-7.mol
solubility | DMSO:62.5(Max Conc. mg/mL);102.52(Max Conc. mM) |
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form | Solid |
color | Off-white to light yellow |
FDA UNII | LH20W7B0Q8 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
CC-90011 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0113540 | CC-90011benzenesulfonate 99.39% | 2097523-60-7 | 5mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0113540 | CC-90011benzenesulfonate 99.39% | 2097523-60-7 | 10mg | $250 | 2021-12-16 | Buy |
ChemScene | CS-0113540 | CC-90011benzenesulfonate 99.39% | 2097523-60-7 | 50mg | $850 | 2021-12-16 | Buy |
ChemScene | CS-0113540 | CC-90011benzenesulfonate 99.39% | 2097523-60-7 | 100mg | $1450 | 2021-12-16 | Buy |
DC Chemicals | DC26140 | CC-90011besylate >98% | 2097523-60-7 | 1g | $2400 | 2021-12-16 | Buy |
CC-90011 Chemical Properties,Uses,Production
Uses
CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].
in vivo
CC-90011 (5 mg/kg; oral administration; daily; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models[1].
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice[1].
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%[1].
Animal Model: | BALB/c nude mice bearing small cell lung carcinoma (SCLC)[1] |
Dosage: | 5 mg/kg |
Administration: | Oral administration; daily; for 30 days |
Result: | Showed a tumor growth inhibition (TGI) of 78% at 5 mg/kg with no body weight loss. |
IC 50
KDM1/LSD1
References
[1] Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DOI:10.1021/acs.jmedchem.0c00978
CC-90011 Preparation Products And Raw materials
Raw materials
Preparation Products
CC-90011 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18146 | 56 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4601 | 55 | |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
View Lastest Price from CC-90011 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-04-27 | Pulrodemstat benzenesulfonate
2097523-60-7
|
US $55.00-126.00 / mg | 97.73% | 10g | TargetMol Chemicals Inc. | ||
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2024-11-19 | Pulrodemstat benzenesulfonate
2097523-60-7
|
US $55.00-126.00 / mg | 97.73% | 10g | TargetMol Chemicals Inc. |
-
- Pulrodemstat benzenesulfonate
2097523-60-7
- US $55.00-126.00 / mg
- 97.73%
- TargetMol Chemicals Inc.
-
- Pulrodemstat benzenesulfonate
2097523-60-7
- US $55.00-126.00 / mg
- 97.73%
- TargetMol Chemicals Inc.