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CC-90011

CC-90011 Structure
CC-90011 structure
CAS No.
2097523-60-7
Chemical Name:
CC-90011
Synonyms
CC-90011;CC-90011 besylate;CC-90011 besylicacid;LSD1-IN-7 benzenesulfote;CC-90011 benzenesulfonate;LSD1-IN-7 benzenesulfonate;Pulrodemstat benzenesulfonate;Pulrodemstat (CC90011) besylate;Pulrodemstat benzenesulfonate, 10 mM in DMSO;CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
CBNumber:
CB55544449
Molecular Formula:
C30H29F2N5O5S
Molecular Weight:
609.65
MDL Number:
MFCD32644589
MOL File:
2097523-60-7.mol
Last updated:2025-04-18 09:51:10
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CC-90011 Properties

solubility DMSO:62.5(Max Conc. mg/mL);102.52(Max Conc. mM)
form Solid
color Off-white to light yellow
FDA UNII LH20W7B0Q8

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

CC-90011 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 5mg $150 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 10mg $250 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 50mg $850 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 100mg $1450 2021-12-16 Buy
DC Chemicals DC26140 CC-90011besylate >98% 2097523-60-7 1g $2400 2021-12-16 Buy
Product number Packaging Price Buy
CS-0113540 5mg $150 Buy
CS-0113540 10mg $250 Buy
CS-0113540 50mg $850 Buy
CS-0113540 100mg $1450 Buy
DC26140 1g $2400 Buy

CC-90011 Chemical Properties,Uses,Production

Uses

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

in vivo

CC-90011 (5 mg/kg; oral administration; daily; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models[1].
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice[1].
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%[1].

Animal Model:BALB/c nude mice bearing small cell lung carcinoma (SCLC)[1]
Dosage:5 mg/kg
Administration:Oral administration; daily; for 30 days
Result:Showed a tumor growth inhibition (TGI) of 78% at 5 mg/kg with no body weight loss.

IC 50

KDM1/LSD1

References

[1] Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DOI:10.1021/acs.jmedchem.0c00978

CC-90011 Preparation Products And Raw materials

Raw materials

Preparation Products

CC-90011 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32202 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38636 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18146 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4601 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
BOC Sciences 65
ChemStrong Scientific Co.,Ltd 56
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Lastest Price from CC-90011 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pulrodemstat benzenesulfonate pictures 2025-04-27 Pulrodemstat benzenesulfonate
2097523-60-7
 US $55.00-126.00 / mg 97.73% 10g TargetMol Chemicals Inc.
Pulrodemstat benzenesulfonate pictures 2024-11-19 Pulrodemstat benzenesulfonate
2097523-60-7
 US $55.00-126.00 / mg 97.73% 10g TargetMol Chemicals Inc.

2097523-60-7(CC-90011)Related Search:

CC-90001 CC-90009 CC-223 CC-92480
CC-90011 besylate CC-90011; CC90011; CC 90011; CC-90011 BESYLATE; CC-90011 LSD1-IN-7 benzenesulfonate LSD1-IN-7 benzenesulfote CC-90011 besylicacid CC-90011 benzenesulfonate Pulrodemstat benzenesulfonate Pulrodemstat (CC90011) besylate 4-(2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile benzenesulfonate LSD1,Pulrodemstat,oral,SCLC,reversible,CC-90011,cell,CC90011,anticancer,Histone Demethylase,differentiation,inhibit,Inhibitor,AML,CC 90011,Pulrodemstat benzenesulfonate Pulrodemstat benzenesulfonate, 10 mM in DMSO 2097523-60-7