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CC-90011

CAS No.
2097523-60-7
Chemical Name:
CC-90011
Synonyms
CC-90011;CC-90011 besylate;CC-90011 besylicacid;LSD1-IN-7 benzenesulfote;CC-90011 benzenesulfonate;LSD1-IN-7 benzenesulfonate;Pulrodemstat benzenesulfonate;Pulrodemstat (CC90011) besylate;Pulrodemstat benzenesulfonate, 10 mM in DMSO;CC-90011; CC90011; CC 90011; CC-90011 BESYLATE;
CBNumber:
CB55544449
Molecular Formula:
C30H29F2N5O5S
Molecular Weight:
609.65
MDL Number:
MFCD32644589
MOL File:
2097523-60-7.mol
Last updated:2025-04-18 09:51:10

CC-90011 Properties

solubility DMSO:62.5(Max Conc. mg/mL);102.52(Max Conc. mM)
form Solid
color Off-white to light yellow
FDA UNII LH20W7B0Q8

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

CC-90011 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 5mg $150 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 10mg $250 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 50mg $850 2021-12-16 Buy
ChemScene CS-0113540 CC-90011benzenesulfonate 99.39% 2097523-60-7 100mg $1450 2021-12-16 Buy
DC Chemicals DC26140 CC-90011besylate >98% 2097523-60-7 1g $2400 2021-12-16 Buy
Product number Packaging Price Buy
CS-0113540 5mg $150 Buy
CS-0113540 10mg $250 Buy
CS-0113540 50mg $850 Buy
CS-0113540 100mg $1450 Buy
DC26140 1g $2400 Buy

CC-90011 Chemical Properties,Uses,Production

Uses

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

in vivo

CC-90011 (5 mg/kg; oral administration; daily; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models[1].
CC-90011 (once a day; for 4 days) treatment results in robust downregulation of GRP mRNA levels at 2.5 mg/kg and maximum suppression of GRP at 5 mg/kg in a SCLC human tumor xenograft (H1417) mice[1].
After i.v. administration, CC-90011 (Compound 11; 5 mg/kg) has systemic clearance of 32.4 mL/min/kg, elimination half-life of 2 h, and a high volume of distribution of 7.5 L/kg. CC-90011 (Compound 11; 5 mg/kg) is readily absorbed after oral administration with an AUC0-24h of 1.8 μM·h, C/sub>max of 0.36 μM, and oral bioavailability of 32%[1].

Animal Model:BALB/c nude mice bearing small cell lung carcinoma (SCLC)[1]
Dosage:5 mg/kg
Administration:Oral administration; daily; for 30 days
Result:Showed a tumor growth inhibition (TGI) of 78% at 5 mg/kg with no body weight loss.

IC 50

KDM1/LSD1

References

[1] Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DOI:10.1021/acs.jmedchem.0c00978

CC-90011 Preparation Products And Raw materials

Raw materials

Preparation Products

CC-90011 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32202 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38636 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18146 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4601 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60

View Lastest Price from CC-90011 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pulrodemstat benzenesulfonate pictures 2025-04-27 Pulrodemstat benzenesulfonate
2097523-60-7
US $55.00-126.00 / mg 97.73% 10g TargetMol Chemicals Inc.
Pulrodemstat benzenesulfonate pictures 2024-11-19 Pulrodemstat benzenesulfonate
2097523-60-7
US $55.00-126.00 / mg 97.73% 10g TargetMol Chemicals Inc.

2097523-60-7(CC-90011)Related Search:

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