NTP-42
- CAS No.
- 2055599-51-2
- Chemical Name:
- NTP-42
- Synonyms
- NTP-42;NTP42, 10 mM in DMSO;N-(tert-Butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-[1,1'-biphenyl]-3-yl)oxy)benzenesulfonamide;pulmonary,Inhibitor,inhibit,PAH,NTP 42,NTP-42,NTP42,hypertension,TXA2,thromboxane,arterial,Prostaglandin Receptor;Benzenesulfonamide, 5-cyano-2-[[4'-(difluoromethoxy)[1,1'-biphenyl]-3-yl]oxy]-N-[[(1,1-dimethylethyl)amino]carbonyl]-
- CBNumber:
- CB55582386
- Molecular Formula:
- C25H23F2N3O5S
- Molecular Weight:
- 515.53
- MDL Number:
- MFCD32669796
- MOL File:
- 2055599-51-2.mol
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 31.25 mg/mL (60.62 mM) |
| form | Solid |
| pka | 4.56±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 2057H3EG0S |
NTP-42 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0108127 | NTP42 98.43% | 2055599-51-2 | 5mg | $175 | 2021-12-16 | Buy |
| ChemScene | CS-0108127 | NTP42 98.43% | 2055599-51-2 | 10mg | $275 | 2021-12-16 | Buy |
| ChemScene | CS-0108127 | NTP42 98.43% | 2055599-51-2 | 100mg | $1125 | 2021-12-16 | Buy |
NTP-42 Chemical Properties,Uses,Production
Uses
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].
in vivo
NTP42 (0.25 mg/kg BID) is potent in a monocrotaline (MCT)-induced PAH rat model (28-day drug treatment is initiated within 24 h post-MCT) in haemodynamic assessments. NTP42 reduces the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP). Moreover, NTP42 is superior to Sildenafil (HY-15025) and Selexipag (HY-14870) in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[2].
| Animal Model: | Male Wistar-Kyoto rats[2] |
| Dosage: | 0.25 mg/kg BID |
| Administration: | 28-day drug treatment was initiated within 24 h post-MCT (60 mg/kg) |
| Result: | Reduced the MCT-induced PAH, including mPAP and RSVP. |
IC 50
TXA2
References
[1] B. Therese KINSELLA, et al. Thromboxane receptor antagonists. WO2016203314A1.
[2] Eamon Mulvaney, et al. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
NTP-42 Preparation Products And Raw materials
Raw materials
Preparation Products
NTP-42 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 996 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10123 | 58 |
