NS-3-008（HCl）
- CAS No.
- 1172854-54-4
- Chemical Name:
- NS-3-008（HCl）
- Synonyms
- NS-3-008;NS-3-008（HCl）;NS-3-008 hydrochloride;NS-3-008 hydrochloride, 10 mM in DMSO;1-Benzyl-3-hexylguanidine hydrochloride;N-BENZYL-N'-HEXYLGUANIDINE HYDROCHLORIDE;N-BENZYL-N'-HEXYLGUANIDINE HYDROCHLORIDE;Guanidine,N-hexyl-N'-(phenylmethyl)-,hydrochloride(1:1);renal,inhibit,Ccl2,NS3008 hydrochloride,Hsd17b4,Stat5,transcriptional,Inhibitor,dysfunction,ameliorate,CKD,NS 3 008 hydrochloride,p65,G0s2
- CBNumber:
- CB55851721
- Molecular Formula:
- C14H24ClN3
- Molecular Weight:
- 269.82
- MDL Number:
- MFCD03931143
- MOL File:
- 1172854-54-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
NS-3-008（HCl） price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L159182 | N-BENZYL-N''-HEXYLGUANIDINE HYDROCHLORIDE AldrichCPR | 1172854-54-4 | 25MG | $29.8 | 2024-03-01 | Buy |
| DC Chemicals | DC20478 | NS-3-008HCl >98% | 1172854-54-4 | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC20478 | NS-3-008HCl >98% | 1172854-54-4 | 1g | $1700 | 2021-12-16 | Buy |
NS-3-008（HCl） Chemical Properties,Uses,Production
Uses
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1].
in vivo
NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1].
References
[1] Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273. DOI:10.1016/j.ebiom.2016.10.008
NS-3-008（HCl） Preparation Products And Raw materials
Raw materials
Preparation Products
NS-3-008（HCl） Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12814 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
View Lastest Price from NS-3-008（HCl） manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | NS-3-008 hydrochloride
1172854-54-4
|
US $38.00-106.00 / mg | 99.56% | 10g | TargetMol Chemicals Inc. |
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- NS-3-008 hydrochloride
1172854-54-4
- US $38.00-106.00 / mg
- 99.56%
- TargetMol Chemicals Inc.