HSP70 modulator 115-7c
- CAS No.
- 908074-72-6
- Chemical Name:
- HSP70 modulator 115-7c
- Synonyms
- Compound 115-7c;HSP70 modulator 115-7c;1(2H)-Pyrimidinebutanoic acid, 4-(2,4-dichlorophenyl)-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-
- CBNumber:
- CB55867564
- Molecular Formula:
- C23H22Cl2N2O5
- Molecular Weight:
- 477.34
- MDL Number:
- MOL File:
- 908074-72-6.mol
Boiling point | 688.6±55.0 °C(Predicted) |
---|---|
Density | 1.360±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 20 mg/ml). |
pka | 4.73±0.10(Predicted) |
form | solid |
color | Off-white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
HSP70 modulator 115-7c Chemical Properties,Uses,Production
Description
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1?The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.2?Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.3,4?Compound 115-7c is an important probe for understanding HSP70 functions.4
Definition
ChEBI: 4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid is a carboxylic ester. It is functionally related to a benzyl alcohol.
References
1) Wisen?et al. (2010),?Binding of a small molecule at the protein-protein interface regulates the chaperone activity of hsp70-hsp40;? ACS Chem. Biol.,?5?611 2) Jinwal?et al. (2010),?Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;? Mol. Cell Pharmacol.,?2?43 3) Chafekar?et al. (2012),?Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;? ACS Chem. Biol.,?7?1556 4) Walter?et al. (2011),?Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;? J. Biol. Chem.,?286?40486
HSP70 modulator 115-7c Preparation Products And Raw materials
Raw materials
Preparation Products
HSP70 modulator 115-7c Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
Supplier | Advantage |
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Nanjing Shizhou Biology Technology Co.,Ltd | 58 |