BC-DXI-843
- CAS No.
- 2421117-98-6
- Chemical Name:
- BC-DXI-843
- Synonyms
- BC-Dxl-843;BC-DXI-843;BC-DXI-843, 10 mM in DMSO;Inhibitor,lung,A549,BCDXI843,AIMP2-DX2,cancer,inhibit,BC DXI 843;(S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide;1H-Indole-3-propanamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-α-[[(4-methylphenyl)sulfonyl]amino]-, (αS)-;(S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide , BC-DXI-843
- CBNumber:
- CB56187890
- Molecular Formula:
- C28H26N4O4S2
- Molecular Weight:
- 546.66
- MDL Number:
- MFCD32693926
- MOL File:
- 2421117-98-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BC-DXI-843 Chemical Properties,Uses,Production
Uses
BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with an IC50 of 0.92 μM, more than 100-fold selectivity over AIMP2 (IC50 >100 μM) in a luciferase assay. BC-DXI-843 acts as a promising lead targeting AIMP2-DX2 in lung cancer[1].
in vivo
BC-DXI-843 (50 mg/kg; intraperitoneally administered; every other day for 15 days) demonstrates in vivo efficacy in a tumor xenograft mouse model (H460 cells)[1].
| Animal Model: | 7-week-old female BALB/cSLC-nu/nu mice bearing H460 cells xenograft[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneally administered; every other day for 15 days |
| Result: | The embedded tumor volume gradually declined after BC-DXI-843administration, but no changes in body weight were observed. The weight of the excised tumors after sacrifice had decreased in mice. |
References
[1] Aneesh Sivaraman, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020 May 28;63(10):5139-5158. DOI:10.1021/acs.jmedchem.9b01961
BC-DXI-843 Preparation Products And Raw materials
Raw materials
Preparation Products
BC-DXI-843 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 947 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
View Lastest Price from BC-DXI-843 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | BC-DXI-843
2421117-98-6
|
US $56.00-173.00 / mg | 98.85% | 10g | TargetMol Chemicals Inc. |
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- BC-DXI-843
2421117-98-6
- US $56.00-173.00 / mg
- 98.85%
- TargetMol Chemicals Inc.