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Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine structure

CAS No.: 67579-81-1

Chemical Name:: Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

Synonyms: (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine;t-DMACH;trans-N1,N2-DiMethylcyclohexane-1,2-diaMine;trans-N,N;TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE;TRANS-N,N'-DIMETHYLCYCLOHEXANE-1,2-DIAMINE;trans-N,N'-DimethyL;TRANS-N,N'-DIMETHYLCYCLOHEXANE;(1R,2R)-rel-N1,N2-Dimethyl-1,2-cycloh;trans-N,N'-DiMethylcyclohexane-1,2-diaMin

CBNumber:: CB5674518

Molecular Formula:: C8H18N2

Molecular Weight:: 142.24

MDL Number:: MFCD03001702

MOL File:: 67579-81-1.mol

MSDS File:: SDS

Last updated:2024-04-12 23:00:59

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Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Properties

Melting point	4°C
Boiling point	83 °C / 13mmHg
Density	0.89
refractive index	n20/D1.472(lit.)
Flash point	60℃
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	11.04±0.40(Predicted)
form	liquid
color	colorless to pale yellow
Sensitive	air sensitive
InChI	InChI=1/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/s3
InChIKey	JRHPOFJADXHYBR-HTQZYQBOSA-N
SMILES	[C@@H]1(NC)CCCC[C@H]1NC \|&1:0,7,r\|
CAS DataBase Reference	67579-81-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38-34-22

Safety Statements

26-36/37/39-45

RIDADR

2735

WGK Germany

HazardClass

PackingGroup

Ⅱ

HS Code

2921309990

NFPA 704

	2
3		0

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	633089	trans-N,N′-Dimethylcyclohexane-1,2-diamine 97%	67579-81-1	5ml	$225	2024-03-01	Buy
Sigma-Aldrich	633089	trans-N,N′-Dimethylcyclohexane-1,2-diamine 97%	67579-81-1	25ml	$772	2024-03-01	Buy
TCI Chemical	D2946	trans-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(T)	67579-81-1	1g	$31	2024-03-01	Buy
TCI Chemical	D2946	trans-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(T)	67579-81-1	5g	$90	2024-03-01	Buy
Strem Chemicals	07-0270	trans-N,N'-Dimethyl-1,2-cyclohexanediamine, 98%	67579-81-1	500mg	$60	2024-03-01	Buy

Product number	Packaging	Price	Buy
633089	5ml	$225	Buy
633089	25ml	$772	Buy
D2946	1g	$31	Buy
D2946	5g	$90	Buy
07-0270	500mg	$60	Buy

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Chemical Properties,Uses,Production

Uses

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine used with CuI to form a general and highly efficient catalyst for the N-amidation of aryl and heteroaryl iodides, bromides and in some cases, unactivated aryl chlorides. The catalyst system is also used for the N-arylation of indoles.

Description

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine is a useful research chemical for organic synthesis and other chemical processes.

Uses

trans-N,N′-dimethylcyclohexane-1,2-diamine can be used as a ligand in the synthesis of the following products via copper catalyzed C-N coupling reactions:

vinylsulfoximines obtained from NH sulfoximes and vinyl bromides
N-arylpyridones obtained via reaction between 2-substituted pyridines and aryl halides
N-aryl amines obtained via reaction between amines and aryl iodides/aryl bromides

Synthesis

Cyclohexene oxide (1) was reacted with 25–30% aqueous methylamine (1.5 equiv.) in a sealed reactor to form trans-2-(methylamino)cyclohexanol 2 at 80 °C within 5h. Compound 2 was subjected to Mitsunobu reaction at room temperature, followed by adjusting the pH from 2 to 10 to yield 7-methyl-7-azabicyclo[4.1.0]-heptane 3, which was directly subjected to the following reaction without purification. Ring-opening reactions of compound 3 with a methylamine aqueous solution were completed in a sealed reactor at 110 °C after 6h to yield Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine.

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Suppliers

Global( 233)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Konberd Biotech Co., Ltd	+undefined18986093962	admin@konberdbio.com	China	1376	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7514	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58

Supplier	Advantage
Wuhan Konberd Biotech Co., Ltd	58
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Chembon Pharmaceutical Co., Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-01	trans-N,N'-Dimethyl-1,2-cyclohexanediamine 67579-81-1	US $17.00-114.00 / g	5g	0.98	25kg	Shanghai UCHEM Inc.
	2019-07-06	Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine 67579-81-1	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

trans-N,N'-Dimethyl-1,2-cyclohexanediamine
67579-81-1
US $17.00-114.00 / g
0.98
Shanghai UCHEM Inc.

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine
67579-81-1
US $1.00 / KG
99%
Career Henan Chemical Co

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine Spectrum

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine(67579-81-1)¹HNMR

67579-81-1(Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine)Related Search:

TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE trans-1,2-Bis(methylamino)cyclohexane, (R,R)-(-)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (1R,2R)-(+)-1,2-DIAMINOCYCLOHEXANE-N,N'-BIS(2'-DIPHENYLPHOSPHINOBENZOYL) (1R,2R)-(+)-1,2-DIAMINOCYCLOHEXANE-N,N'-BIS(2-DIPHENYLPHOSPHINO-1-NAPHTHOYL) N,N'-Dimethyl-1,2-cyclohexanediamine

Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine 1,2-Cyclohexylenedinitrilotetraacetic acid (1S)-trans-1,2-Bis(methylamino)cyclohexane, (S,S)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (+/-)-TRANS-1,2-BIS(2-MERCAPTOACETAMIDO)CYCLOHEXANE TRANS-1,2-DIAMINOCYCLOHEXANE-N,N,N',N'-TETRAACETIC ACID MONOHYDRATE

(-)-N,N'-(1R,2R)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE) (+/-)-TRANS-1,2-BIS(THIOACETATEACETAMIDO)CYCLOHEXANE (+)-U-50488 HYDROCHLORIDE (+/-)-TRANS-1,2-BIS(CHLOROACETAMIDO)CYCLOHEXANE (1R,2R)-N,N,N''N''-TETRAMETHYL-1,2-CYCLOHEXANEDIAMINE

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride (4AR,8AR)-DECAHYDRO-QUINOXALINE

1of4

trans-(1R,2R)-N,N'-BisMethyl-1,2-cyclohexanedia 1,2-CyclohexanediaMine,N1,N2-diMethyl-, (1R,2R)-rel- trans-N,N'-DiMethylcyclohexane-1,2-diaMin rel-(1R,2R)-N1,N2-DiMethylcyclohexane-1,2-diaMine (1R,2R)-rel-N1,N2-DiMethylcyclohexane-1,2-diaMine trans-N,N'-Dimethyl-1,2-cyclohexanediamine,98% TRANS-N,N''-DIMETHYL-1,2-CYCLOHEXANEDIAMINE (1R,2R)-rel-N1,N2-Dimethyl-1,2-cyclohexanediamine (+/-)-trans-1,2-Diamino-N,N'-dimethylcyclohexane rel-(1R,2R)-1-N,2-N-diMethylcyclohexane-1,2-diaMine Trans-(1R,2R)-N,N'-bisMehtyl-1,2-cyclohexanediaMine (1R,2R)-rel-N1,N2-Dimethyl-1,2-cyclohexanediamine (Oxaliplatin) (1R,2R)-rel-N1,N2-Dimethyl-1,2-cycloh trans-1,2-Bis(methylamino)cyclohexane (Oxaliplatin) TRANS-N,N'-DIMETHYLCYCLOHEXANE trans-N,N'-Bismethyl-1,2-cyclohexanediamine N,N'-Dimethyl-trans-1,2-cyclohexanediamine trans-N,N'-Dimethylcyclohexane-1,2-diamine> trans-N,N'-DimethyL 1,2-Cyclohexanediamine, N,N'-dimethyl-, (1R,2R)-rel- rans-N,N'-dimethylcyclohexane-1,2-diamine Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine ISO 9001：2015 REACH C8H18N2 TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE 67579-81-1 trans-N,N TRANS-1,2-BIS(METHYLAMINO)CYCLOHEXANE TRANS-N,N'-DIMETHYLCYCLOHEXANE-1,2-DIAMINE (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine t-DMACH trans-N1,N2-DiMethylcyclohexane-1,2-diaMine Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine trans-N,N'-Dimethyl-1,2-cyclohexanediamine trans-N,N'-Dimethylcyclohexane-1,2-diamine trans-N,N'-Bismethyl-1,2-cyclohexanediamine 67579-81-1 C6H10NHCH32 Chiral Nitrogen DACH&Trost Series Chiral Reagents Miscellaneous Reagents