2-Methylpropanedioic acid
- CAS No.
- 516-05-2
- Chemical Name:
- 2-Methylpropanedioic acid
- Synonyms
- METHYLMALONIC ACID;2-Methylmalonic acid;AI315327;NSC 25201;onic acid;AI3 15327;AI3-15327;Methylmalonic;isosuccinicacid;Isosuccinic acid
- CBNumber:
- CB5713714
- Molecular Formula:
- C4H6O4
- Molecular Weight:
- 118.09
- MDL Number:
- MFCD00002656
- MOL File:
- 516-05-2.mol
- MSDS File:
- SDS
Melting point | 128-130 °C (lit.) |
---|---|
Boiling point | 272.71°C (rough estimate) |
Density | 1.45 |
refractive index | 1.4304 (estimate) |
Flash point | 2℃ |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Crystalline Powder |
pka | 3.07, 5.76(at 25℃) |
color | White |
Specific Gravity | 1.455 |
PH | 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution) |
Water Solubility | soluble |
BRN | 1756084 |
CAS DataBase Reference | 516-05-2(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 8LL8S712J7 |
NIST Chemistry Reference | Methylmalonic acid(516-05-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi,Xn,F | |||||||||
Risk Statements | 36/37/38-36-20/21/22-11 | |||||||||
Safety Statements | 26-36/37-16 | |||||||||
RIDADR | UN 1648 3 / PGII | |||||||||
WGK Germany | 3 | |||||||||
RTECS | OO1400000 | |||||||||
HS Code | 29171900 | |||||||||
NFPA 704 |
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2-Methylpropanedioic acid price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M54058 | Methylmalonic acid 99% | 516-05-2 | 5g | $65.8 | 2024-03-01 | Buy |
Sigma-Aldrich | M-080 | Methylmalonic acid solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 516-05-2 | 1mL | $113 | 2024-03-01 | Buy |
TCI Chemical | M0568 | Methylmalonic Acid >98.0%(T) | 516-05-2 | 25g | $74 | 2024-03-01 | Buy |
Cayman Chemical | 14885 | Methylmalonate ≥95% | 516-05-2 | 1g | $20 | 2024-03-01 | Buy |
Cayman Chemical | 14885 | Methylmalonate ≥95% | 516-05-2 | 5g | $48 | 2024-03-01 | Buy |
2-Methylpropanedioic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Methylmalonic acid can be used as a substrate in:
- Esterification reactions by various catalysts.
- Synthesis of pyrimidinium betaines with formamidine.
- Synthesis of malonic acid half thioester (MAHT).
Uses
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
Definition
ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).
Biological Functions
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
General Description
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
storage
Store at RT
Purification Methods
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
2-Methylpropanedioic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 | yezhaobao@yfpharm.com | China | 27 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
View Lastest Price from 2-Methylpropanedioic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-05-15 | 2-Methylpropanedioic acid
516-05-2
|
US $0.00-0.00 / KG | 5KG | 99% | 1000 kg/Month | Xiamen Yunfan Biotech Co.,Ltd. | |
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2023-08-24 | 2-Methylpropanedioic acid
516-05-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
|
2021-04-27 | 2-Methylpropanedioic acid
516-05-2
|
US $1.00 / PCS | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 2-Methylpropanedioic acid
516-05-2
- US $0.00-0.00 / KG
- 99%
- Xiamen Yunfan Biotech Co.,Ltd.
-
- 2-Methylpropanedioic acid
516-05-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 2-Methylpropanedioic acid
516-05-2
- US $1.00 / PCS
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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