Swertisin
- CAS No.
- 6991-10-2
- Chemical Name:
- Swertisin
- Synonyms
- Tris(1;SWERTISIN;SWERTISIN(P);Swertisin-RM;Swertia flavin;Genkwanin 6-C-Glucoside;3-dichloroisopropyl)phosphate;APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER;4',5-Dihydroxy-7-methoxy-6-β-D-glucopyranosylflavone;Swertisin, 98%, from Swertia diluta (Turcz.) Benth. & Hook.f.
- CBNumber:
- CB5724709
- Molecular Formula:
- C22H22O10
- Molecular Weight:
- 446.4
- MDL Number:
- MFCD32003920
- MOL File:
- 6991-10-2.mol
| Melting point | 245-246℃ |
|---|---|
| Boiling point | 716.6±60.0 °C(Predicted) |
| Density | 1.583±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO; sparingly soluble in methanol; |
| pka | 5.76±0.40(Predicted) |
| form | powder |
| color | White-pale yellow |
| Water Solubility | slightly soluble in water |
Swertisin price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83912 | Swertisin phyproof? Reference Substance | 6991-10-2 | 10MG | $377.4 | 2024-03-01 | Buy |
| Usbiological | 301021 | Swertisin | 6991-10-2 | 10mg | $581 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259583 | Swertisin 98% | 6991-10-2 | 5mg | $596.7 | 2021-12-16 | Buy |
| ChemScene | CS-0019497 | Swertisin | 6991-10-2 | 5mg | $686 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS74200 | Swertisin | 6991-10-2 | 10mg | $510 | 2021-12-16 | Buy |
Swertisin Chemical Properties,Uses,Production
Chemical Properties
Swertisin is a flavonoid compound that appears as a light yellow powder or crystalline powder at room temperature. Its chemical formula is C22H22O10, with a molecular weight of 446. it is soluble in organic solvents such as methanol and dimethyl sulfoxide. It has antioxidant,anti-diabetic, anti-depressant, anti-inflammatory, anti-viral, and anti-radiation pharmacological effects.
Definition
ChEBI: Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin.
Biological Activity
Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities. It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 μg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 μM). Swertisin (0.2-5 μM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells. It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.
References
[1] GURPRIT BHARDWAJ . Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy[J]. Archives of biochemistry and biophysics, 2021, 710: Article 108995. DOI:10.1016/j.abb.2021.108995.
[2] K. PATEL D. P. Biological importance and therapeutic benefit of swertisin: An overview of medicinal importance and pharmacological activities[J]. Current Bioactive Compounds, 2022. DOI:10.2174/1573407218666220801113334.
[3] HONG-YAN XU . Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim[J]. Journal of ethnopharmacology, 2020, 257: Article 112787. DOI:10.1016/j.jep.2020.112787.
Swertisin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
View Lastest Price from Swertisin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Swertisin
6991-10-2
|
US $64.00-393.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Swertisin
6991-10-2
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-02-21 | APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
6991-10-2
|
US $8.00 / KG | 1g | ＞98% HPLC | kg--ton | Career Henan Chemical Co |
-
- Swertisin
6991-10-2
- US $64.00-393.00 / mg
- 99.79%
- TargetMol Chemicals Inc.
-
- Swertisin
6991-10-2
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
6991-10-2
- US $8.00 / KG
- ＞98% HPLC
- Career Henan Chemical Co