L-Hyoscyamine
- CAS No.
- 101-31-5
- Chemical Name:
- L-Hyoscyamine
- Synonyms
- HYOSCYAMINE;APOA;(-)-Hycosamine;AK38;L-(P);Levsin;SEPSECS;Levsinex;DATURINE;Cystospaz
- CBNumber:
- CB5772230
- Molecular Formula:
- C17H23NO3
- Molecular Weight:
- 289.37
- MDL Number:
- MFCD00067306
- MOL File:
- 101-31-5.mol
| Melting point | 108,5°C |
|---|---|
| Boiling point | 431.53°C (rough estimate) |
| alpha | D20 -21.0° (alc) |
| Density | 1.0470 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | 2-8°C |
| solubility |
DMSO:79.0(Max Conc. mg/mL);273.0(Max Conc. mM) Ethanol:58.0(Max Conc. mg/mL);200.43(Max Conc. mM) |
| form | powder |
| pka | pKa (21°) 9.7 |
| color | white |
| Water Solubility | 3.6g/L(20 ºC) |
| Merck | 14,4858 |
| InChIKey | RKUNBYITZUJHSG-FXUDXRNXSA-N |
| LogP | 1.380 (est) |
| CAS DataBase Reference | 101-31-5(CAS DataBase Reference) |
| FDA UNII | V3203SI72M |
| NIST Chemistry Reference | Hyoscyamine(101-31-5) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)- (101-31-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330-H370 | |||||||||
| Precautionary statements | P260-P264-P270-P271-P284-P301+P310+P330-P304+P340+P310-P307+P311-P403+P233-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28 | |||||||||
| Safety Statements | 24-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NH0875000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29339900 | |||||||||
| Hazardous Substances Data | 101-31-5(Hazardous Substances Data) | |||||||||
| Toxicity | man,LDLo,unreported,1471ug/kg (1.471mg/kg),"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |||||||||
| NFPA 704 |
|
L-Hyoscyamine price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | HPA070409 | Anti-SEPSECS antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 101-31-5 | 100μL | $580 | 2024-03-01 | Buy |
| Sigma-Aldrich | HPA070409 | Anti-SEPSECS antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 101-31-5 | 25μL | $282 | 2023-06-20 | Buy |
| Cayman Chemical | 25644 | (?)-Hyoscyamine ≥98% | 101-31-5 | 250mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 25644 | (?)-Hyoscyamine ≥98% | 101-31-5 | 500mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 25644 | (?)-Hyoscyamine ≥98% | 101-31-5 | 1g | $87 | 2024-03-01 | Buy |
L-Hyoscyamine Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Uses
L-Hyoscyamine can be used as anticholinergic and analgesic.
Uses
L-Hyoscyamine is a natural compound that has inhibitory activity against cholinesterases.
Definition
ChEBI: An atropine with a 2S-configuration.
General Description
Hyoscyamine is a levorotatory alkaloidobtained from various solanaceous species. One ofthe commercial sources is Egyptian henbane (Hyoscyamusmuticus), in which it occurs to the extent of about 0.5%.Usually, it is prepared from the crude drug in a manner similarto that used for atropine and is purified as the oxalate.The free base is obtained easily from this salt.
It occurs as white needles that are sparingly soluble inwater (1:281), more soluble in ether (1:69) or benzene(1:150), very soluble in chloroform (1:1), and freely solublein alcohol. It is used as the sulfate and hydrobromide. Theprincipal reason for the popularity of the hydrobromide hasbeen its nondeliquescent nature. The salts have the advantageover the free base in being quite water soluble.
Biochem/physiol Actions
The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM]
Clinical Use
(L-Hyoscyamine)Hyoscyamine is used to treat disorders of the urinarytract more so than any other antispasmodic, although thereis no evidence that it has any advantages over the otherbelladonna preparations and the synthetic anticholinergics.It is used to treat spasms of the bladder and, in this manner,serves as a urinary stimulant. It is used together witha narcotic to counteract the spasm produced by the narcoticwhen the latter is used to relieve the pain of urethral colic.Hyoscyamine preparations are also used as antispasmodicsin the therapy of peptic ulcers.
target
AChR
L-Hyoscyamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18941 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29879 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from L-Hyoscyamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Hyoscyamine
101-31-5
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 100 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-01-31 | L-Hyoscyamine
101-31-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2021-07-02 | L-Hyoscyamine
101-31-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Hyoscyamine
101-31-5
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- L-Hyoscyamine
101-31-5
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- L-Hyoscyamine
101-31-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd