PATULIN
- CAS No.
- 149-29-1
- Chemical Name:
- PATULIN
- Synonyms
- PAT;mycoin;Terinin;CLAVACIN;clavatin;expansin;patuline;penicidin;expansine;clairformin
- CBNumber:
- CB5780754
- Molecular Formula:
- C7H6O4
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD00005858
- MOL File:
- 149-29-1.mol
| Melting point | 108-111 °C |
|---|---|
| alpha | D21 -6.2° (chloroform) |
| Boiling point | 197.46°C (rough estimate) |
| Density | 1.1993 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| Flash point | 2℃ |
| storage temp. | −20°C |
| solubility | ethyl acetate: soluble50mg/mL |
| pka | 11.69±0.20(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White |
| Merck | 13,7125 |
| BRN | 149675 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 149-29-1(CAS DataBase Reference) |
| FDA UNII | 95X2BV4W8R |
| IARC | 3 (Vol. 40, Sup 7) 1987 |
| EPA Substance Registry System | Patulin (149-29-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352-P332+P313 | |||||||||
| Hazard Codes | T,Xn,C,F | |||||||||
| Risk Statements | 25-38-48/20/22-40-22-34-11-36-20/21/22-67-36/38-20-63 | |||||||||
| Safety Statements | 45-36/37-36/37/39-26-16 | |||||||||
| RIDADR | UN 3462 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LV2625000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 s.c. in mice: 10-15 mg/kg (Kinosita, Shikata) | |||||||||
| NFPA 704 |
|
PATULIN price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CRM46914 | Patulin solution certifiedreferencematerial,100?μg/mLinchloroform,ampuleof1?mL | 149-29-1 | 1mL | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | 34127 | Patulin solution 100μg/mL in acetonitrile, analytical standard | 149-29-1 | 2ml | $683 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32759 | Patulin reference material | 149-29-1 | 5mg | $806 | 2022-05-15 | Buy |
| Cayman Chemical | 11346 | Patulin ≥98% | 149-29-1 | 5mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 11346 | Patulin ≥98% | 149-29-1 | 10mg | $135 | 2024-03-01 | Buy |
PATULIN Chemical Properties,Uses,Production
Description
Spergillus and Penicillium species. Patulin is also an animal carcinogen, inhibits K1-uptake into erythrocytes, and inhibits various forms of Na1/K1-ATPase.
Chemical Properties
white crystals or fine crystalline powder
Uses
Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products.
Uses
An inhibitor of protein prenylation
Definition
ChEBI: A furopyran and lactone that is 2H-pyran-3(6H)-ylidene)acetic acid which is syubstituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give he corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.
Purification Methods
Crystallise patulin from *C6H6, Et2O, EtOH or chloroform. It sublimes at 90o/high vacuum [Bergel et al. J Chem Soc 415 1944]. [Beilstein 18 III/IV 1184, 18/3 V 5.] (Highly TOXIC).
References
1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455 2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92 3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343 4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1 5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328
PATULIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
View Lastest Price from PATULIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-04 | PATULIN
149-29-1
|
US $72.00-367.00 / mg | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-09-07 | PATULIN
149-29-1
|
US $0.00 / KG | 25KG | 97% | 1tone | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-02 | PATULIN
149-29-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |