Disitamab Vedotin
- CAS No.
- 2136633-23-1
- Chemical Name:
- Disitamab Vedotin
- Synonyms
- RC48;Disitamab Vedotin;Disitamab vedotin (ADC)
- CBNumber:
- CB58081127
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | Store at 4°C, protect from light |
|---|---|
| form | Solid |
| color | White to light yellow |
| FDA UNII | RB3U3A1S27 |
Disitamab Vedotin Chemical Properties,Uses,Production
Uses
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity[1].
IC 50
HER2
References
[1] Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935. DOI:10.1007/s40265-021-01614-x
[2] Jiang J, et al. Preclinical safety profile of disitamab vedotin: a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37. DOI:10.1016/j.toxlet.2019.12.027
[3] Huang L, Wang R, Xie K, et al. A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+?tumors in hPD-1 transgenic mouse model and contributes immune memory formation. Breast Cancer Res Treat. 2022;191(1):51-61. DOI:10.1007/s10549-021-06384-4
Disitamab Vedotin Preparation Products And Raw materials
Raw materials
Preparation Products
Disitamab Vedotin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10356 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24642 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Wuhan Peptide Core Biotechnology Co., Ltd | 027-65317797 13667154760 | 1096814016@qq.com | China | 10711 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509; 17721492509 | 643638326@qq.com | China | 4944 | 58 |
| bioleaper | 4000880777 17585207275 | guojing@bioleaper.com | China | 5616 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9913 | 58 |