ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT
- CAS No.
- Chemical Name:
- ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT
- Synonyms
- MONOCLONAL ANTI-PIAS-X;ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT;Monoclonal Anti-PIAS-x antibody produced in mouse
- CBNumber:
- CB5820856
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD08705595
- MOL File:
- Mol file
ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT Chemical Properties,Uses,Production
Uses
Monoclonal Anti-PIAS-x antibody produced in mouse may be used in:
- enzyme-linked immunosorbent assay (ELISA)
- immunocytochemistry
- immunoblotting
General Description
Monoclonal Anti-PIAS-x (mouse IgG1isotype) is derived from the PIASX-116 hybridoma produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice. Protein inhibitor of activated STAT 2 (PIAS2/PIAS-x), a small ubiquitin-like modifier (SUMO) E3 ligase contains a zinc binding motif and a highly acidic region. This gene is located on human chromosome 18q21.1.
Biochem/physiol Actions
Protein inhibitor of activated STAT2 (PIAS2) plays a key role in SUMO modification (SUMOylation) of several host and viral proteins. PIAS-x acts as a transcriptional co-repressor of STAT4. It may participate in controlling the chromatin structure. Upregulation or suppression of this gene can control the stability of the hepatitis C virus (HCV) core, NS3 and NS5A proteins. Hence PIAS-x is considered as the restriction factor for HCV replication.
ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-PROTEIN INHIBITOR OF ACTIVATOR STAT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |