Ceramide AP
- CAS No.
- 212070-45-6
- Chemical Name:
- Ceramide AP
- Synonyms
- Ceramide AP;Water soluble Ceramide VI;Sphingomyelin Impurity 8 (Ceramide VI);Octadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy-
- CBNumber:
- CB58366512
- Molecular Formula:
- C36H73NO5
- Molecular Weight:
- 599.97
- MDL Number:
- MOL File:
- 212070-45-6.mol
| Boiling point | 748.3±60.0 °C(Predicted) |
|---|---|
| Density | 0.967±0.06 g/cm3(Predicted) |
| pka | 13.26±0.20(Predicted) |
| InChIKey | BBAFBDLICMHBNU-MFZOPHKMSA-N |
| SMILES | C(N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)(=O)C(O)CCCCCCCCCCCCCCCC |
| FDA UNII | F1X8L2B00J |
Ceramide AP Chemical Properties,Uses,Production
Description
Ceramide AP (CER [AP]; AP stands for α-hydroxy-N-stearoylphytosphingosine) belongs to a larger group of ceramides that are naturally occurring, long chains of lipids (fats) in the skin. To put it into perspective, the skin’s general composition of ceramides is around 50%; of that, 16% of those ceramides are of the AP variety. CERs are sphingolipids that contain a sphingoid moiety (which can be sphingosine (S), dihydrosphingosine (D), phytosphingosine (P) or 6-hydroxy-sphingosine (H)), linked with a long-chain FFA moiety (which can be nonhydroxy (N), α-hydroxy (A) or ester-linked ω-hydroxy (EO)) through an amide bond. Research indicated that CER [AP], with four hydroxyl groups on its head group, can form super stable membranes through strong hydrogen bonds. It has also been shown to be antiproliferative and proapoptotic in numerous cancer cell types in vitro. Therefore, administration of CER [AP] to the skin might help to restore the barrier function of aged and affected skin[1–2].
Definition
ChEBI: N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine is a phytoceramide in which the ceramide N-acyl group is specified as 2-hydroxyoctadecanoyl
References
[1] Fitsum F. Sahle . “Polyglycerol fatty acid ester surfactant–based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterisation, in vitro release and penetration investigation.” European Journal of Pharmaceutics and Biopharmaceutics 82 1 (2012): Pages 139-150.
[2] Fitsum F Sahle. “Lecithin-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterizations, and in vitro release and penetration studies.” Pharmaceutical Research 30 2 (2013): 538–51.
Ceramide AP Preparation Products And Raw materials
Raw materials
Preparation Products
Ceramide AP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 326 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 8472 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3147 | 58 |
| Shandong Dexiang International Trade Co., Ltd | 15662695772;+8615662691337 | sales006@dexiangchemical.com | China | 998 | 58 |
| Puripharm Co., Ltd. | 0572-2745768-1 13167223168 | sales@puripharm.com | China | 297 | 65 |
| Shandong Juntai Pharmaceutical Co. LTD | 15853135817 | baiyang@h2opharm.com | China | 154 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2815987 13927875076 | 3007432263@qq.com | China | 9977 | 58 |
| Wuhan Xinru Chemical Industry Co., Ltd | 15927387915 | 2162228368@qq.com | China | 3409 | 58 |
| Henan Vcommend Consultrading Co., Ltd. | 13393721940 | sales@vcommend.com | China | 9938 | 58 |
View Lastest Price from Ceramide AP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-30 | Water soluble Ceramide VI
212070-45-6
|
US $0.00-0.00 / kg | 0.1kg | 98% HPLC | 20000kgs | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
-
- Water soluble Ceramide VI
212070-45-6
- US $0.00-0.00 / kg
- 98% HPLC
- Chongqing Zhihe Biopharmaceutical Co., Ltd.