Heptafluorobutyric acid
- CAS No.
- 375-22-4
- Chemical Name:
- Heptafluorobutyric acid
- Synonyms
- HFBA;Perfluorobutanoic acid;PERFLUOROBUTYRIC ACID;2,2,3,3,4,4,4-Heptafluorobutanoic acid;PERFLUOROBUTYRATE;Perfluorobutanoicaid;heptafluorobutanoicacid;FC-23;H 0024;NSC 820
- CBNumber:
- CB5853573
- Molecular Formula:
- C4HF7O2
- Molecular Weight:
- 214.04
- MDL Number:
- MFCD00004171
- MOL File:
- 375-22-4.mol
- MSDS File:
- SDS
| Melting point | -17.5 °C |
|---|---|
| Boiling point | 120 °C755 mm Hg(lit.) |
| Density | 1.645 g/mL at 25 °C(lit.) |
| vapor density | 7 (vs air) |
| vapor pressure | ~10 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 120-121°C |
| storage temp. | Store below +30°C. |
| solubility | Chloroform: soluble; Methanol: soluble |
| form | Powder |
| pka | pK1:0.17 (25°C) |
| Specific Gravity | approximate 1.6 |
| color | Clear colorless to faint yellow |
| PH | 1 (H2O, 20℃) |
| Water Solubility | miscible |
| Sensitive | Light Sensitive |
| BRN | 1426882 |
| InChIKey | YPJUNDFVDDCYIH-UHFFFAOYSA-N |
| CAS DataBase Reference | 375-22-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 12VHZ8L29I |
| NIST Chemistry Reference | Butanoic acid, heptafluoro-(375-22-4) |
| EPA Substance Registry System | Heptafluorobutyric acid (375-22-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-35 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ET4025000 | |||||||||
| F | 3-8-10 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | T | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159000 | |||||||||
| NFPA 704 |
|
Heptafluorobutyric acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.43443 | Heptafluorobutyric acid for synthesis | 375-22-4 | 5ML | $43.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.43443 | Heptafluorobutyric acid for synthesis | 375-22-4 | 25ML | $75.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 52411 | Heptafluorobutyric acid for ion chromatography, ≥99.5% (GC) | 375-22-4 | 5ml | $46.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 52411 | Heptafluorobutyric acid for ion chromatography, ≥99.5% (GC) | 375-22-4 | 25mL | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | 164194 | Heptafluorobutyric acid 98% | 375-22-4 | 5g | $31.7 | 2024-03-01 | Buy |
Heptafluorobutyric acid Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to faintly yellow liquid
Uses
Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.
Uses
Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
Uses
Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.
Definition
ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.
General Description
Perfluorobutyric acid is an effective additive for zinc electrodeposition.
Hazard
Irritant to tissue.
Purification Methods
Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]
Heptafluorobutyric acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1376 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| BEYOND INDUSTRIES (CHINA) LIMITED | +86-21-52699951; +8613917686115 | sales@beyondindustriesgroup.com | China | 699 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
View Lastest Price from Heptafluorobutyric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-03 | Heptafluorobutyric acid
375-22-4
|
US $0.00 / KG | 1KG | 95% ,98% | 10000 | Wuhan Silworld Chemical Co.,Ltd | |
 |
2019-07-06 | Heptafluorobutyric acid
375-22-4
|
US $1.00 / KG | 1KG | 99% | 200KG | Career Henan Chemical Co |
-
- Heptafluorobutyric acid
375-22-4
- US $0.00 / KG
- 95% ,98%
- Wuhan Silworld Chemical Co.,Ltd
-
- Heptafluorobutyric acid
375-22-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co